ArticlePharmaceutical research2008
Preparation of BMP-2 containing bovine serum albumin (BSA) nanoparticles stabilized by polymer coating.
Article in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 102 citations in OpenAlex.
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- Protein nanoparticles directed cancer imaging and therapy.Nano convergence · 2022Review
- Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy.Colloids and surfaces. B, Biointerfaces · 2021Article
- Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment.Molecules (Basel, Switzerland) · 2020Review
- Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems.Critical reviews in biotechnology · 2018Review
- Delivery of stromal cell-derived factor 1α forJournal of biological engineering · 2017Review
- Preparation of Curcumin Loaded Egg Albumin Nanoparticles Using Acetone and Optimization of Desolvation Process.The protein journal · 2016Article
- Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation.Drug design, development and therapy · 2015Article
- Comparison of Different Crosslinking Methods for Preparation of Docetaxel-loaded Albumin Nanoparticles.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Protein nanoparticles as drug delivery carriers for cancer therapy.BioMed research international · 2014Review
- Effect of different sintering methods on bioactivity and release of proteins from PLGA microspheres.Materials science & engineering. C, Materials for biological applications · 2013Article
- The novel albumin-chitosan core-shell nanoparticles for gene delivery: preparation, optimization and cell uptake investigation.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the preparation process of bone morphogenetic protein-2 (BMP-2) containing bovine serum albumin (BSA) nanoparticles (NPs), and to assess the bioactivity of BMP-2 encapsulated in such NPs.
methodsThe NPs were prepared by a coacervation method, and the effects of process parameters on NP size and polydispersity were examined. Polymer coated NPs were characterized with respect to amount of adsorbed polymer, particle size and zeta potential. Using bone marrow stromal cells (BMSC), biocompatibility of the NPs was investigated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) Assay, and bioactivity of the encapsulated BMP-2 was investigated by alkaline phosphatase (ALP) induction and calcification.
resultsThe size of NPs could be controlled in the 50-400 nm range by process parameters including BSA concentration, non-solvent:solvent ratio and pH value. After coating with cationic polymers, the particle size and zeta potential were significantly increased. MTT assay indicated no toxicity of both the uncoated and coated NPs on BMSC. Based on ALP induction and calcification, full retention of BMP-2 bioactivity was retained in the polymer-coated NPs.
conclusionsThis study described a preparation procedure for BSA NPs with controllable particle size, and such polymer-coated BSA NPs are promising delivery agents for local and systemic administration of BMP-2 in bone regeneration.
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