ArticleEnvironmental health perspectives2008
Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies.Environmental science & technology · 2026Pooled it
- From genes to organs: physiological responses of European chub (Frontiers in toxicology · 2025Article
- Association between Perfluoroalkyl and Polyfluoroalkyl Substances and Women's Infertility, NHANES 2013-2016.International journal of environmental research and public health · 2022Article
- Perfluorooctanoic Acid Affects Thyroid Follicles in Common Carp (International journal of environmental research and public health · 2022Article
- Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP1.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Next generation per- and poly-fluoroalkyl substances: Status and trends, aquatic toxicity, and risk assessment.Eco-Environment & Health · 2022Review
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.Environmental toxicology and chemistry · 2021Review
- Shedding new light on early sex determination in zebrafish.Archives of toxicology · 2020Article
- PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field.International journal of environmental research and public health · 2020Review
- Effects of perfluorooctanoic acid (PFOA) on the thyroid status, vitellogenin, and oxidant-antioxidant balance in the Murray River rainbowfish.Ecotoxicology (London, England) · 2020Article
- Perfluorinated compounds binding to estrogen receptor of different species: a molecular dynamic modeling.Journal of molecular modeling · 2018Article
- PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.Toxicology · 2017Article
- Common carp Cyprinus carpio responses to sub-chronic exposure to perfluorooctanoic acid.Environmental science and pollution research international · 2016Article
- Perfluorinated compounds affect the function of sex hormone receptors.Environmental science and pollution research international · 2013Article
- Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Review
- Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells.Environmental science and pollution research international · 2011Article
- Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Epigenetics meets endocrinology.Journal of molecular endocrinology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPerfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are considered refractory to carcinogenesis by PPs. Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure.
objectivesIn this study, we used trout as a unique in vivo tumor model to study the potential for PFOA carcinogenesis in the absence of peroxisome proliferation compared with the structurally diverse PPs clofibrate (CLOF) and DHEA. Mechanisms of carcinogenesis were identified from hepatic gene expression profiles phenotypically anchored to tumor outcome.
methodsWe fed aflatoxin B(1) or sham-initiated animals 200-1,800 ppm PFOA in the diet for 30 weeks for tumor analysis. We subsequently examined gene expression by cDNA array in animals fed PFOA, DHEA, CLOF, or 5 ppm 17beta-estradiol (E(2), a known tumor promoter) in the diet for 14 days.
resultsPFOA (1,800 ppm or 50 mg/kg/day) and DHEA treatments resulted in enhanced liver tumor incidence and multiplicity (p < 0.0001), whereas CLOF showed no effect. Carcinogenesis was independent of peroxisome proliferation, measured by lack of peroxisomal beta-oxidation and catalase activity. Alternately, both tumor promoters, PFOA and DHEA, resulted in estrogenic gene signatures with strong correlation to E(2) by Pearson correlation (R = 0.81 and 0.78, respectively), whereas CLOF regulated no genes in common with E(2).
conclusionsThese data suggest that the tumor-promoting activities of PFOA in trout are due to novel mechanisms involving estrogenic signaling and are independent of peroxisome proliferation.
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