Evidence map›Paper›PMID 18708580›Full record

ArticleGenes & development2008

Identification of cis-acting sites for condensin loading onto budding yeast chromosomes.

Claudio D'Ambrosio, Christine Katrin Schmidt, Yuki Katou, Gavin Kelly, Takehiko Itoh, Katsuhiko Shirahige, Frank Uhlmann

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 336 citations in OpenAlex.

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  19. Genome control by SMC complexes.Nature reviews. Molecular cell biology · 2023
    Review
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168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Claudio D'AmbrosioChromosome Segregation Laboratory, Cancer Research UK London Research Institute, London, UK.
Christine Katrin Schmidt
Yuki Katou
Gavin Kelly
Takehiko Itoh
Katsuhiko Shirahige
Frank Uhlmann
Cancer Research UK · GBTokyo Institute of Technology · JPMitsubishi Research Institute (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and SNR genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.

Indexed as

MitosisTranscription, GeneticAdenosine TriphosphatasesBinding SitesCell CycleCell Cycle ProteinsChromatin Assembly and DisassemblyChromatin ImmunoprecipitationChromosomal Proteins, Non-HistoneChromosomes, FungalCohesinsDNA-Binding ProteinsFungal ProteinsMultiprotein ComplexesRNA Polymerase IIIRNA, TransferAdenosine TriphosphatasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinscondensin complexesDNA-Binding ProteinsFungal ProteinsMultiprotein ComplexesRNA Polymerase IIIRNA, TransferTranscription Factors, TFIIITranscription Factor TFIIIC

Identifiers

PMID18708580
PMCPMC2518811
OpenAlexW2097483873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.