SynthesisApplied and environmental microbiology2008
Meta-analysis of experimental data concerning antimicrobial resistance gene transfer rates during conjugation.
Synthesis in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantifying conjugation rates in clinical and environmental matrices: a systematic review to inform risk assessment.Frontiers in microbiomes · 2024Pooled it
- Effect of donor-recipient relatedness on the plasmid conjugation frequency: a meta-analysis.BMC microbiology · 2020Pooled it
- Comparative genomics of blood and faecal E. coli and K. pneumoniae isolates from neonates with bloodstream infections in Tanzania.Communications biology · 2025Article
- Multidrug-resistant E. Coli in wastewater sources: a comparative study and identification of resistance hotspots.BMC microbiology · 2025Article
- A bayesian approach for parameterizing and predicting plasmid conjugation dynamics.Scientific reports · 2025Article
- Article
- Prevalence and characterization of quinolone-resistantJournal of advanced veterinary and animal research · 2023Article
- Development of a high-throughput platform to measure plasmid transfer frequency.Frontiers in cellular and infection microbiology · 2023Article
- Tetracycline Gene Transfer inFrontiers in microbiology · 2019Article
- Pathogenic Escherichia coli producing Extended-Spectrum β-Lactamases isolated from surface water and wastewater.Scientific reports · 2015Article
- Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance.Environmental health perspectives · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This paper presents the results of a meta-analysis of published transfer rates of antimicrobial resistance genes. A total of 34 papers were identified, of which 28 contained rates estimated in relation to either donor or recipient bacterial counts. The published rates ranged from 10(-2) to 10(-9). Generalized linear modeling was conducted to identify the factors influencing this variation. Highly significant associations between transfer frequency and both the donor (P = 1.2 x 10(-4)) and recipient (P = 1.0 x 10(-5)) genera were found. Also significant was whether the donor and recipient strains were of the same genus (P = 0.023) and the nature of the genetic element (P = 0.0019). The type of experiment, in vivo or in vitro, approached statistical significance (P = 0.12). Parameter estimates from a general linear model were used to estimate the probability of transfer of antimicrobial resistance genes to potential pathogens in the intestine following oral ingestion. The mean logarithms of these probabilities are in the range of [-7.0, -3.1]. These probability distributions are suitable for use in the quantitative assessment of the risk of transfer of antimicrobial resistance genes to the intestinal flora of humans and animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.