ArticleBiophysical journal2008
Phenomenological model and phase behavior of saturated and unsaturated lipids and cholesterol.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
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- Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction, and Validation.The journal of physical chemistry. B · 2016Article
- Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes.The Journal of chemical physics · 2014Article
- Critical behaviour in DOPC/DPPC/cholesterol mixtures: static (2)H NMR line shapes near the critical point.Biophysical journal · 2014Article
- Formation and domain partitioning of H-ras peptide nanoclusters: effects of peptide concentration and lipid composition.Journal of the American Chemical Society · 2012Article
- Self-consistent mean-field model for palmitoyloleoylphosphatidylcholine-palmitoyl sphingomyelin-cholesterol lipid bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2011Article
- Simulation of the lo-ld phase boundary in DSPC/DOPC/cholesterol ternary mixtures using pairwise interactions.The journal of physical chemistry. B · 2011Article
- A simple thermodynamic model of the liquid-ordered state and the interactions between phospholipids and cholesterol.Biophysical journal · 2011Article
- Orientation of tie-lines in the phase diagram of DOPC/DPPC/cholesterol model biomembranes.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Membrane microheterogeneity: Förster resonance energy transfer characterization of lateral membrane domains.European biophysics journal : EBJ · 2010Review
- Lateral organization of complex lipid mixtures from multiscale modeling.The Journal of chemical physics · 2010Article
- Hybrid lipids as a biological surface-active component.Biophysical journal · 2009Article
- Theory of raft formation by the cross-linking of saturated or unsaturated lipids in model lipid bilayers.Biophysical journal · 2009Article
- An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes.Biochimica et biophysica acta · 2009Review
- What drives the clustering of membrane-bound Ras?Small GTPasesArticle
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We present a phenomenological theory for the phase behavior of ternary mixtures of cholesterol and saturated and unsaturated lipids, one that describes both liquid and gel phases. It leads to the following description of the mechanism of the phase behavior: In a binary system of the lipids, phase separation occurs when the saturated chains are well ordered, as in the gel phase, simply due to packing effects. In the liquid phase, the saturated ones are not sufficiently well ordered for separation to occur. The addition of cholesterol, however, increases the saturated lipid order to the point that phase separation is once again favorable. Our theory addresses this last mechanism-the means by which cholesterol-mediated ordering of membrane lipids leads to liquid-liquid immiscibility. It produces, for the system above the main chain transition of the saturated lipid, phase diagrams in which there can be liquid-liquid phase separation in the ternary system but not in any of the binary ones, while below that temperature it yields the more common phase diagram in which a gel phase, rich in saturated lipid, appears in addition to the two liquid phases.
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