ArticleBiophysical journal2008
Hemoglobin dynamics in red blood cells: correlation to body temperature.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance.Medical sciences (Basel, Switzerland) · 2026Review
- Model for small-angle scattering analysis of membranes with protein-like inclusions.Journal of applied crystallography · 2025Article
- The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure.National science review · 2023Article
- Cooperative Change in the Internal Dynamics of Streptavidin Caused by Biotin Binding.The journal of physical chemistry. B · 2023Article
- Molecular rotors in haemoglobin and bovine serum albumin proteins.Journal of the Royal Society, Interface · 2022Article
- Short-Time Transport Properties of Bidisperse Suspensions of Immunoglobulins and Serum Albumins Consistent with a Colloid Physics Picture.The journal of physical chemistry. B · 2022Article
- Exploring the Limits of Biological Complexity Amenable to Studies by Incoherent Neutron Spectroscopy.Life (Basel, Switzerland) · 2022Review
- The alternative proteome in neurobiology.Frontiers in cellular neuroscience · 2022Review
- Effect of Temperature and Flow Rate on the Cell-Free Area in the Microfluidic Channel.Membranes · 2021Article
- Dynamics of proteins with different molecular structures under solution condition.Scientific reports · 2020Article
- Effect of red blood cell shape changes on haemoglobin interactions and dynamics: a neutron scattering study.Royal Society open science · 2020Article
- Interaction of blood plasma proteins with superhemophobic titania nanotube surfaces.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- Temperature dependence of nanoscale dynamic processes measured in living millipedes by high resolution inelastic and elastic neutron scattering.Scientific reports · 2019Article
- Deep UV dispersion and absorption spectroscopy of biomolecules.Biomedical optics express · 2019Article
- Microscopic diffusion processes measured in living planarians.Scientific reports · 2018Article
- Photoactivation Reduces Side-Chain Dynamics of a LOV Photoreceptor.Biophysical journal · 2016Article
- Article
- Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.Journal of the Royal Society, Interface · 2014Article
- Correlation between supercoiling and conformational motions of the bacterial flagellar filament.Biophysical journal · 2013Article
- Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences.BMC biophysics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transition in hemoglobin behavior at close to body temperature has been discovered recently by micropipette aspiration experiments on single red blood cells (RBCs) and circular dichroism spectroscopy on hemoglobin solutions. The transition temperature was directly correlated to the body temperatures of a variety of species. In an exploration of the molecular basis for the transition, we present neutron scattering measurements of the temperature dependence of hemoglobin dynamics in whole human RBCs in vivo. The data reveal a change in the geometry of internal protein motions at 36.9 degrees C, at human body temperature. Above that temperature, amino acid side-chain motions occupy larger volumes than expected from normal temperature dependence, indicating partial unfolding of the protein. Global protein diffusion in RBCs was also measured and the findings compared favorably with theoretical predictions for short-time self-diffusion of noncharged hard-sphere colloids. The results demonstrated that changes in molecular dynamics in the picosecond time range and angstrom length scale might well be connected to a macroscopic effect on whole RBCs that occurs at body temperature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.