ArticleBiophysical journal2008
The activity of the amphipathic peptide delta-lysin correlates with phospholipid acyl chain structure and bilayer elastic properties.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- pH-triggered pore-forming peptides with strong composition-dependent membrane selectivity.Biophysical journal · 2021Article
- Mechanistic Landscape of Membrane-Permeabilizing Peptides.Chemical reviews · 2019Review
- The Mechanism of Membrane Permeabilization by Peptides: Still an Enigma.Australian journal of chemistry · 2019Article
- Branched phospholipids render lipid vesicles more susceptible to membrane-active peptides.Biochimica et biophysica acta · 2016Article
- Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide.Biophysical journal · 2016Article
- Lysylated phospholipids stabilize models of bacterial lipid bilayers and protect against antimicrobial peptides.Biochimica et biophysica acta · 2014Article
- Expression and characterization of cecropinXJ, a bioactive antimicrobial peptide fromExperimental and therapeutic medicine · 2013Article
- Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells.Biophysical journal · 2012Article
- Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs.Chemistry and physics of lipids · 2011Review
- What determines the activity of antimicrobial and cytolytic peptides in model membranes.Biochemistry · 2011Article
- Antimicrobial peptides: successes, challenges and unanswered questions.The Journal of membrane biology · 2011Review
- Describing the mechanism of antimicrobial peptide action with the interfacial activity model.ACS chemical biology · 2010Review
- Detergent-like activity and alpha-helical structure of warnericin RK, an anti-Legionella peptide.Biophysical journal · 2009Article
- Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics.Biochemistry · 2009Article
- Wasp mastoparans follow the same mechanism as the cell-penetrating peptide transportan 10.Biochemistry · 2009Article
- Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity.Journal of the American Chemical Society · 2009Article
- The role played by lipids unsaturation upon the membrane interaction of the Helicobacter pylori HP(2-20) antimicrobial peptide analogue HPA3.Journal of bioenergetics and biomembranes · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Release of lipid vesicle content induced by the amphipathic peptide delta-lysin was investigated as a function of lipid acyl chain length and degree of unsaturation for a series of phosphatidylcholines. Dye efflux and peptide binding were examined for three homologous lipid series: di-monounsaturated, di-polyunsaturated, and asymmetric phosphatidylcholines, with one saturated and one monounsaturated acyl chain. Except for the third series, peptide activity correlated with the first moment of the lateral pressure profile, which is a function of lipid acyl chain structure. In vesicles composed of asymmetric phosphatidylcholines, peptide binding and dye efflux are enhanced compared to symmetric, unsaturated lipids with similar pressure profiles. We attribute this to the entropically more favorable interaction of delta-lysin with partially saturated phospholipids. We find that lipid acyl chain structure has a major impact on the activity of delta-lysin and is likely to be an important factor contributing to the target specificity of amphipathic peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.