ArticleBiophysical journal2008
New proposed mechanism of actin-polymerization-driven motility.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks.Science advances · 2024Article
- Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks.bioRxiv : the preprint server for biology · 2024Article
- Building a dendritic actin filament network branch by branch: models of filament orientation pattern and force generation in lamellipodia.Biophysical reviews · 2018Review
- Self-propulsion and interactions of catalytic particles in a chemically active medium.Physical review. E · 2016Article
- How capping protein enhances actin filament growth and nucleation on biomimetic beads.Physical biology · 2015Article
- Control of actin-based motility through localized actin binding.Physical biology · 2013Article
- Filament depolymerization can explain chromosome pulling during bacterial mitosis.PLoS computational biology · 2011Article
- A microscopic formulation for the actin-driven motion of listeria in curved paths.Biophysical journal · 2010Article
- Mechano-chemical feedbacks regulate actin mesh growth in lamellipodial protrusions.Biophysical journal · 2010Article
- Actin dynamics: from nanoscale to microscale.Annual review of biophysics · 2010Review
- Force-velocity relation for actin-polymerization-driven motility from Brownian dynamics simulations.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the first numerical simulation of actin-driven propulsion by elastic filaments. Specifically, we use a Brownian dynamics formulation of the dendritic nucleation model of actin-driven propulsion. We show that the model leads to a self-assembled network that exerts forces on a disk and pushes it with an average speed. This simulation approach is the first to observe a speed that varies nonmonotonically with the concentration of branching proteins (Arp2/3), capping protein, and depolymerization rate, in accord with experimental observations. Our results suggest a new interpretation of the origin of motility. When we estimate the speed that this mechanism would produce in a system with realistic rate constants and concentrations as well as fluid flow, we obtain a value that is within an order-of-magnitude of the polymerization speed deduced from experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.