ArticleBiophysical journal2008
Growing actin networks form lamellipodium and lamellum by self-assembly.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- Article
- Vesicle shape transformations driven by confined active filaments.Nature communications · 2021Article
- Article
- Building a dendritic actin filament network branch by branch: models of filament orientation pattern and force generation in lamellipodia.Biophysical reviews · 2018Review
- Actin Turnover in Lamellipodial Fragments.Current biology : CB · 2017Article
- Nano-scale actin-network characterization of fibroblast cells lacking functional Arp2/3 complex.Journal of structural biology · 2017Article
- Model of turnover kinetics in the lamellipodium: implications of slow- and fast- diffusing capping protein and Arp2/3 complex.Physical biology · 2016Article
- The More the Tubular: Dynamic Bundling of Actin Filaments for Membrane Tube Formation.PLoS computational biology · 2016Article
- Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model.BMC systems biology · 2014Article
- Formation of transient lamellipodia.PloS one · 2014Article
- Multiscale modeling of cell shape from the actin cytoskeleton.Progress in molecular biology and translational science · 2014Review
- There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.Biophysical journal · 2013Review
- Distributed actin turnover in the lamellipodium and FRAP kinetics.Biophysical journal · 2013Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Myo1c facilitates G-actin transport to the leading edge of migrating endothelial cells.The Journal of cell biology · 2012Article
- Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front.Biophysical journal · 2012Article
- Membrane tension, myosin force, and actin turnover maintain actin treadmill in the nerve growth cone.Biophysical journal · 2012Article
- Excitable actin dynamics in lamellipodial protrusion and retraction.Biophysical journal · 2012Article
- Robust organizational principles of protrusive biopolymer networks in migrating living cells.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many different cell types are able to migrate by formation of a thin actin-based cytoskeletal extension. Recently, it became evident that this extension consists of two distinct substructures, designated lamellipodium and lamellum, which differ significantly in their kinetic and kinematic properties as well as their biochemical composition. We developed a stochastic two-dimensional computer simulation that includes chemical reaction kinetics, G-actin diffusion, and filament transport to investigate the formation of growing actin networks in migrating cells. Model parameters were chosen based on experimental data or theoretical considerations. In this work, we demonstrate the system's ability to form two distinct networks by self-organization. We found a characteristic transition in mean filament length as well as a distinct maximum in depolymerization flux, both within the first 1-2 microm. The separation into two distinct substructures was found to be extremely robust with respect to initial conditions and variation of model parameters. We quantitatively investigated the complex interplay between ADF/cofilin and tropomyosin and propose a plausible mechanism that leads to spatial separation of, respectively, ADF/cofilin- or tropomyosin-dominated compartments. Tropomyosin was found to play an important role in stabilizing the lamellar actin network. Furthermore, the influence of filament severing and annealing on the network properties is explored, and simulation data are compared to existing experimental data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.