ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk.Scientific reports · 2015Pooled it
- Mammographic density and risk of breast cancer by age and tumor characteristics.Breast cancer research : BCR · 2013Pooled it
- A novel automated mammographic density measure and breast cancer risk.Journal of the National Cancer Institute · 2012Pooled it
- Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case-control study.Journal of clinical laboratory analysis · 2023Article
- Genotypes and Haplotypes in theBritish journal of biomedical science · 2022Article
- Association of AXIN2 s2240308 C>T, rs1133683 C>T, rs7224837 A>G Polymorphisms with Susceptibility to Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies.BMC cancer · 2021Article
- Article
- APC gene 3'UTR SNPs and interactions with environmental factors are correlated with risk of colorectal cancer in Chinese Han population.Bioscience reports · 2020Article
- Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility.Pharmacogenomics and personalized medicine · 2020Article
- Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology.Trends in biochemical sciences · 2019Review
- Identification of key pathways and genes in response to trastuzumab treatment in breast cancer using bioinformatics analysis.Oncotarget · 2018Article
- Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population.BMC medical genetics · 2017Article
- Article
- Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Interaction between APC and Fen1 during breast carcinogenesis.DNA repair · 2016Review
- Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis.Cancer cell international · 2015Article
- Wnt signaling pathway pharmacogenetics in non-small cell lung cancer.The pharmacogenomics journal · 2014Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant Wnt/beta-catenin signaling leading to nuclear accumulation of the oncogene product beta-catenin is observed in a wide spectrum of human malignancies. The destruction complex in the Wnt/beta-catenin pathway is critical for regulating the level of beta-catenin in the cytoplasm and in the nucleus. Here, we report a comprehensive study of the contribution of genetic variation in six genes encoding the beta-catenin destruction complex (APC, AXIN1, AXIN2, CSNK1D, CSNK1E, and GSK3B) to breast cancer using a Mayo Clinic Breast Cancer Case-Control Study. A total of 79 candidate functional and tagging single nucleotide polymorphisms (SNP) were genotyped in 798 invasive cases and 843 unaffected controls. Of these, rs454886 in the APC tumor suppressor gene was associated with increased breast cancer risk (per allele odds ratio, 1.23; 95% confidence intervals, 1.05-1.43; P(trend) = 0.01). In addition, five SNPs in AXIN2 were associated with increased risk of breast cancer (P(trend) < 0.05). Haplotype-based tests identified significant associations between specific haplotypes in APC and AXIN2 (P < or = 0.03) and breast cancer risk. Further characterization of the APC and AXIN2 variants suggested that AXIN2 rs4791171 was significantly associated with risk in premenopausal (P(trend) = 0.0002) but not in postmenopausal women. The combination of our findings and numerous genetic and functional studies showing that APC and AXIN2 perform crucial tumor suppressor functions suggest that further investigation of the contribution of AXIN2 and APC SNPs to breast cancer risk are needed.
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