ArticleExperimental cell research2008
Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices.
Article in Experimental cell research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Evaluation of different rat models intrauterine adhesion models and improvement of the technique for their establishment.Experimental animals · 2023Article
- Magnesium Modifies the Structural Features of Enzymatically Mineralized Collagen Gels Affecting the Retraction Capabilities of Human Dermal Fibroblasts Embedded within This 3D System.Materials (Basel, Switzerland) · 2016Article
- MCPIP1 Regulates Fibroblast Migration in 3-D Collagen Matrices Downstream of MAP Kinases and NF-κB.The Journal of investigative dermatology · 2015Article
- Fibroblast morphogenesis on 3D collagen matrices: the balance between cell clustering and cell migration.Experimental cell research · 2013Review
- Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis.Journal of the American Chemical Society · 2013Article
- The use of porous scaffold as a tumor model.International journal of biomaterials · 2013Article
- The effect of growth factor environment on fibroblast morphological response to substrate stiffness.Biomaterials · 2013Article
- Matrix compositions and the development of breast acini and ducts in 3D cultures.In vitro cellular & developmental biology. Animal · 2010Article
- Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.Experimental cell research · 2010Article
- Vascular smooth muscle cell motility: From migration to invasion.Experimental and clinical cardiology · 2010Article
- Fibroblasts in three dimensional matrices: cell migration and matrix remodeling.Experimental & molecular medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Tractional force exerted by tissue cells in 3D collagen matrices can be utilized for matrix remodeling or cell migration. The interrelationship between these motile processes is not well understood. The current studies were carried out to test the consequences of oncogenic Ras (H-Ras(V12)) transformation on human fibroblast contraction and migration in 3D collagen matrices. Beginning with hTERT-immortalized cells, we prepared fibroblasts stably transformed with E6/E7 and with the combination HPV16 E6/E7 and H-Ras(V12). Oncogenic Ras-transformed cells lost contact inhibition of cell growth, formed colonies in soft agar and were unable to make adherens junctions. We observed no changes in the extent or growth factor dependence of collagen matrix contraction (floating or stress-relaxation) by oncogenic Ras-transformed cells. On the other hand, transformed cells in nested collagen matrices lost not only growth factor selectivity, but also cell-matrix density-dependent inhibition of migration. These findings demonstrate differential regulation of collagen matrix contraction and cell migration in 3D collagen matrices.
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Registered trials
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