Evidence map›Paper›PMID 18707726›Full record

Trial reportThe Journal of urology2008

Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study.

Deborah A Wing, Pamela J Rumney, Christine W Preslicka, Judith H Chung

Open access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 9 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 9 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Antibiotics for asymptomatic bacteriuria in pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Cranberries for preventing urinary tract infections.The Cochrane database of systematic reviews · 2012
    Pooled it
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  11. Trial
  12. Trial
  13. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011
    Trial
  14. Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Deborah A WingDepartment of Obstetrics and Gynecology, University of California, Irvine, Orange, California 92868, USA. mfm@uci.edu
Pamela J Rumney
Christine W Preslicka
Judith H Chung
University of California, Irvine · USMiller Children's & Women's Hospital · US

Funding

Cranberry for Prevention of Bacteriuria in PregnancyR21DK068527 · NIDDK · UNIVERSITY OF CALIFORNIA IRVINE · PI WING, DEBORAH A · 2004 to 2005
$465k
NCI NIH HHS N0T-CA-02-014NIDDK NIH HHS R21 DK068527NIDDK NIH HHS R21DK65827-01
6 · The paper itself

Abstract

purposeWe compared the effects of daily cranberry juice cocktail to those of placebo during pregnancy on asymptomatic bacteriuria and symptomatic urinary tract infections. MATERIALS AND

methodsA total of 188 women were randomized to cranberry or placebo in 3 treatment arms of A-cranberry 3 times daily (58), B-cranberry at breakfast then placebo at lunch and dinner (67), and C-placebo 3 times daily (63). After 27.7% (52 of 188) of the subjects were enrolled in the study the dosing regimens were changed to twice daily dosing to improve compliance.

resultsThere were 27 urinary tract infections in 18 subjects in this cohort, with 6 in 4 group A subjects, 10 in 7 group B subjects and 11 in 7 group C subjects (p = 0.71). There was a 57% and 41% reduction in the frequency of asymptomatic bacteriuria and all urinary tract infections, respectively, in the multiple daily dosing group. However, this study was not sufficiently powered at the alpha 0.05 level (CI 0.14-1.39 and 0.22-1.60, respectively, incidence rate ratios). Of 188 subjects 73 (38.8%) withdrew, most for gastrointestinal upset.

conclusionsThese data suggest there may be a protective effect of cranberry ingestion against asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy. Further studies are planned to evaluate this effect.

Indexed as

Vaccinium macrocarponAdultBacteriuriaBeveragesFemaleFollow-Up StudiesGestational AgeHumansPhytotherapyPilot ProjectsPregnancyPregnancy Complications, InfectiousPregnancy OutcomeReference ValuesRisk AssessmentSeverity of Illness Index

Identifiers

PMID18707726
PMCPMC2631561
OpenAlexW2158520804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.