ArticleBiological psychiatry2008
Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla.
Article in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial.The international journal of neuropsychopharmacology · 2010Trial
- Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research.Neural plasticity · 2022Review
- Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts.Scientific reports · 2021Article
- Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults.Metabolic brain disease · 2017Article
- Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats.Pharmacology, biochemistry, and behavior · 2015Article
- Brain proton magnetic resonance spectroscopy of alcohol use disorders.Handbook of clinical neurology · 2014Review
- Modulating neural plasticity with non-invasive brain stimulation in schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Review
- Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.European archives of psychiatry and clinical neuroscience · 2012Article
- BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity.Translational psychiatry · 2012Article
- BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals.Translational psychiatry · 2011Article
- Rare copy number deletions predict individual variation in human brain metabolite concentrations in individuals with alcohol use disorders.Biological psychiatry · 2011Article
- BDNF Val66Met polymorphism and brain volumes in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Article
- Review
- Decreased BDNF in patients with antipsychotic naïve first episode schizophrenia.Schizophrenia research · 2010Article
- BDNF Val66Met polymorphism and protein levels in amniotic fluid.BMC neuroscience · 2010Article
- Early Life Stress Associated With Increased StriatalChronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 (val66met) polymorphism on measures of N-acetyl-aspartate (NAA) containing compounds in healthy subjects.
methodsThe NAA to creatine (Cre) ratio (NAA/Cre), NAA to choline (Cho) ratio (NAA/Cho), and Cho to Cre ratio (Cho/Cre) were measured in the left and right hippocampi, left and right dorsolateral prefrontal cortices, occipital lobe, anterior cingulate, and white matter of the centrum semiovale of 69 carefully screened healthy volunteers utilizing proton magnetic resonance spectroscopic imaging (MRSI) at 3 Tesla (T).
resultsVal/met subjects exhibited significantly reduced levels of left hippocampal NAA/Cre and NAA/Cho compared with val/val subjects. This effect was independent of age, IQ, number of voxels, hippocampal volume, or gray matter content in the voxels of interest. Analysis of other brain regions showed no effect of BDNF genotype on NAA measures.
conclusionsWe confirmed the association between the met-BDNF variant and reduced levels of hippocampal NAA found with a similar technique at 1.5T. The consonance of our results with prior findings adds to the evidence that the BDNF val/met genotype affects hippocampal biology with implications for a variety of neuropsychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.