ReviewAntioxidants & redox signaling2008
Oxidative stress in the regulation of normal and neoplastic hematopoiesis.
Review in Antioxidants & redox signaling, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
176 citing papers in PubMed, 3 syntheses or guidelines pooled it, 371 citations in OpenAlex.
- Association between red blood cell distribution width and mortality and severity among patients with COVID-19: A systematic review and meta-analysis.Journal of medical virology · 2021Pooled it
- Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review.PloS one · 2016Pooled it
- Pooled it
- Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention.Journal of thrombosis and thrombolysis · 2013Trial
- Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes.Haematologica · 2012Trial
- Impact of altered heme oxygenase-1 in caring for preterm neonates: navigating the unknown.Pediatric research · 2026Review
- Relationship between red cell distribution width to albumin ratio (RAR) and mortality in ICU patients with sepsis-associated ARDS: a retrospective study based on MIMIC-IV.BMC infectious diseases · 2026Article
- Red Blood Cell Distribution Width-to-Albumin Ratio (RAR) Is an Independent Predictor of Mortality in Non-Anemic Elderly with Hip Fractures.International journal of general medicine · 2026Article
- Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death.EMBO reports · 2025Article
- Association between the red cell distribution width-to-platelet ratio and 30-day all-cause mortality among patients with acute respiratory failure: a retrospective analysis of the MIMIC-IV database.BMC pulmonary medicine · 2025Article
- Discovery of Anti-Aging Effects of Wheat Bran Extract in a D-Galactose-Induced Rat Model of Oxidative Stress.Nutrients · 2025Article
- Article
- Red Cell Distribution Width as a Predictive Biomarker for Early Lung Injury in Pediatric Patients Following Cardiopulmonary Bypass.Children (Basel, Switzerland) · 2025Article
- Oxidative Stress Score as a Simplified Surrogate for Prognostic Stratification and Therapeutic Decision-Making in Multiple Myeloma.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Review
- Admission Red Blood Cell Distribution Width and Mean Platelet Volume as Predictors of Mortality in the Pediatric Intensive Care Unit: A Five-Year Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- Role of selenium in the pathophysiology of cardiorenal anaemia syndrome.ESC heart failure · 2025Review
- The relationship between red blood cell distribution width and long-term prognosis of asthma: a population-based study.Scientific reports · 2025Article
- The Impact of Sodium Selenite and Seleno-L-Methionine on Stress Erythropoiesis in a Murine Model of Hemolytic Anemia.The Journal of nutrition · 2025Article
- A Practical Nomogram Based on RDW-CV for Predicting Clinical Outcome in Elderly Septic Patients.Infection and drug resistance · 2025Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent evidence suggests that oxidative stress contributes significantly to the regulation of hematopoietic cell homeostasis. In particular, red blood cells and hematopoietic stem cells are highly sensitive to deregulated accumulation of reactive oxygen species (ROS). Unchecked ROS accumulation often leads to hemolysis, that is, to destruction and shortened life span of red blood cells. In addition, the process of erythroid cell formation is sensitive to ROS accumulation. Similarly, ROS buildup in hematopoietic stem cells compromises their function as a result of potential damage to their DNA leading to loss of quiescence and alterations of hematopoietic stem cell cycling. These abnormalities may lead to accelerated aging of hematopoietic stem cells or to hematopoietic malignancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.