ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
PPARG by dietary fat interaction influences bone mass in mice and humans.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 66 citations in OpenAlex.
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- Deletion of SREBF1, a Functional Bone-Muscle Pleiotropic Gene, Alters Bone Density and Lipid Signaling in Zebrafish.Endocrinology · 2021Article
- Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.PLoS genetics · 2020Article
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- Differential effects of high fat diet and diet-induced obesity on skeletal acquisition in female C57BL/6J vs. FVB/NJ Mice.Bone reports · 2018Article
- Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study.Current osteoporosis reports · 2015Review
- Diet and gene interactions influence the skeletal response to polyunsaturated fatty acids.Bone · 2014Article
- Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.The Journal of clinical investigation · 2014Article
- Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women.PloS one · 2014Article
- Impact of the environment on the skeleton: is it modulated by genetic factors?Current osteoporosis reports · 2013Review
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- Variants associated with sex differences related to body fat distribution.BoneKEy reports · 2013Article
- Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice.Experimental eye research · 2012Article
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- Low fatness, reduced fat intake and adequate plasmatic concentrations of LDL-cholesterol are associated with high bone mineral density in women: a cross-sectional study with control group.Lipids in health and disease · 2012Article
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Authors and funding
19 authors at 8 institutions in 3 countries.
Funding
Abstract
Adult BMD, an important risk factor for fracture, is the result of genetic and environmental interactions. A quantitative trait locus (QTL) for the phenotype of volumetric BMD (vBMD), named Bmd8, was found on mid-distal chromosome (Chr) 6 in mice. This region is homologous to human Chr 3p25. The B6.C3H-6T (6T) congenic mouse was previously created to study this QTL. Using block haplotyping of the 6T congenic region, expression analysis in the mouse, and examination of nonsynonymous SNPs, peroxisome proliferator activated receptor gamma (Pparg) was determined to be the most likely candidate gene for the Bmd8 QTL of the 630 genes located in the congenic region. Furthermore, in the C3H/HeJ (C3H) strain, which is the donor strain for the 6T congenic, several polymorphisms were found in the Pparg gene. On challenge with a high-fat diet, we found that the 6T mouse has a lower areal BMD (aBMD) and volume fraction of trabecular bone (BV/TV%) of the distal femur compared with B6 mice. Interactions between SNPs in the PPARG gene and dietary fat for the phenotype of BMD were examined in the Framingham Offspring Cohort. This analysis showed that there was a similar interaction of the PPARG gene and diet (fat intake) on aBMD in both men and women. These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene.
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