ArticleDrug safety2008
Advice on drug safety in pregnancy: are there differences between commonly used sources of information?
Article in Drug safety, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reference guides for the safe use of drugs during pregnancy: a systematic review and comparative analysis.European journal of clinical pharmacology · 2024Pooled it
- Analysis of queries to a Swedish drug information centre identifies scientific knowledge gaps.Scientific reports · 2024Article
- Assessment of the scope, completeness, and consistency of various drug information resources related to COVID-19 medications in pregnancy and lactation.BMC pregnancy and childbirth · 2023Article
- Identifying target areas of medicines information efforts to pregnant and breastfeeding women by reviewing questions to SafeMotherMedicine: A Norwegian web-based public medicines information service.BMC pregnancy and childbirth · 2022Article
- Use of Prescribed Drugs to Treat Chronic Diseases during Pregnancy in Outpatient Care in Switzerland between 2014 and 2018: Descriptive Analysis of Swiss Health Care Claims Data.International journal of environmental research and public health · 2022Article
- PregTox: A Resource of Knowledge about Drug Fetal Toxicity.BioMed research international · 2022Article
- Implications of self-medication in pregnancy for Safe Motherhood and Sustainable Development Goal-3 in selected Ghanaian communities.Public health in practice (Oxford, England) · 2020Article
- SafeMotherMedicine: Aiming to Increase Women's Empowerment in Use of Medications During Pregnancy and Breastfeeding.Maternal and child health journal · 2020Article
- Norwegian drug information centres strongly promote person-centred and personalised medicine: a brief report on the achievements and strategy.The EPMA journal · 2019Review
- Use of antimigraine medications and information needs during pregnancy and breastfeeding: a cross-sectional study among 401 Norwegian women.European journal of clinical pharmacology · 2016Article
- Pregnancy and lactation advice: How does Australian Product Information compare with established information resources?Obstetric medicine · 2016Article
- Assessing the information in the Summaries of Product Characteristics for the use of medicines in pregnancy and lactation.British journal of clinical pharmacology · 2015Article
- Multiple information sources and consequences of conflicting information about medicine use during pregnancy: a multinational Internet-based survey.Journal of medical Internet research · 2014Article
- Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers.European journal of clinical pharmacology · 2013Article
- Which factors predict the time spent answering queries to a drug information centre?Pharmacy world & science : PWS · 2010Article
- Clinical pharmacology consultation: a better answer to safety issues of drug therapy during pregnancy?European journal of clinical pharmacology · 2010Article
- Perception of risk regarding the use of medications and other exposures during pregnancy.European journal of clinical pharmacology · 2010Article
- Depression during pregnancy: views on antidepressant use and information sources of general practitioners and pharmacists.BMC health services research · 2009Article
- Drug use in pregnancy--physicians' evaluation of quality and clinical impact of drug information centres.European journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveSafety regarding use in pregnancy is not established for many drugs. Inconsistencies between sources providing drug information can give rise to confusion with possible therapeutic consequences. Therefore, it is important to measure clinically important differences between drug information sources. The objective of this study was to compare two easily accessible Norwegian sources providing advice on drug safety in pregnancy - the product monographs in the Felleskatalog (FK), published by the pharmaceutical companies, and the five regional Drug Information Centres (DICs) in Norway - in addition to assessing the frequency of questions regarding drug safety in pregnancy made to the DICs according to the Anatomical Therapeutic Chemical (ATC) classification system.
methodsAdvice on drug use in pregnancy provided by the DICs in 2003 and 2005 were compared with advice in the product monographs for the respective drugs in the FK. Comparison of advice was based on categorization to one of four categories: can be used, benefit-risk assessment, should not be used, or no available information.
resultsA total of 443 drug advice were categorized. Seven out of ten of drugs frequently enquired about, according to the ATC system, were drugs acting on the nervous system (group N). For 208 (47%) of the drugs, advice differed between the DICs and FK. Advice from the FK was significantly (p < 0.01) more restrictive than advice from the DICs. There were no differences in the level of consistency of advice between drugs that were newly introduced and those that had been on the market for a longer time, advice regarding use of drugs in the first trimester and advice regarding use of drugs in the second or third trimester, or between advice provided during 2003 and during 2005.
conclusionsThe results of this study show considerable differences between two Norwegian sources providing advice on the use of drugs in pregnancy. Based on the knowledge that healthcare providers choose sources of information in a random manner, our results may be of clinical importance. We believe that the problem with heterogeneous drug information on this subject is not confined to Norway and that our results should be of international interest.
Indexed as
Identifiers
18707194What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.