ArticleThrombosis research2009
Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis.
Article in Thrombosis research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The Na/K-ATPase α1 subunit fine-tunes platelet P2Y12 function and mediates sex dimorphism-associated thrombosis.Blood advances · 2026Article
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- Small RNA sequencing and identification of papaya (Carica papaya L.) miRNAs with potential cross-kingdom human gene targets.Molecular genetics and genomics : MGG · 2022Article
- Establishment of a Modified and Standardized Ferric Chloride-Induced Rat Carotid Artery Thrombosis Model.ACS omega · 2022Article
- Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice.International journal of molecular sciences · 2020Article
- Lipoprotein receptor signalling in atherosclerosis.Cardiovascular research · 2020Review
- New Insights in the Pathophysiology of Antiphospholipid Syndrome.Seminars in thrombosis and hemostasis · 2018Review
- Ferric Chloride-induced Murine Thrombosis Models.Journal of visualized experiments : JoVE · 2016Article
- High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population.PloS one · 2015Article
- Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.Biochimica et biophysica acta · 2014Article
- A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene.Circulation. Cardiovascular genetics · 2014Article
- Article
- Ferric chloride-induced murine carotid arterial injury: A model of redox pathology.Redox biology · 2013Article
- Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice.World journal of experimental medicine · 2012Article
- Association of ApoE genetic polymorphisms with proximal deep venous thrombosis.Journal of thrombosis and thrombolysis · 2012Article
- Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Lack of association of common polymorphism of LRP1 gene with myocardial infarction in a Chinese Han population.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Article
- Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.The Journal of biological chemistry · 2010Article
- Type 2 scavenger receptor CD36 in platelet activation: the role of hyperlipemia and oxidative stress.Clinical lipidology · 2009Article
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Authors and funding
5 authors.
Funding
Abstract
introductionOur group has previously reported genetic studies associating polymorphisms in the low density lipoprotein receptor related protein 8 (LRP8) gene with myocardial infarction. The aim of this study was to define the role of platelet surface LRP8 in thrombosis. MATERIALS AND
methodsFlow cytometry, aggregometry, intravital microscopy and tail bleeding assays were used to examine platelet function and hemostasis in LRP8-deficient mice and littermate controls.
resultsWe demonstrated that activation of platelets from both LRP8(+/-) and LRP8(-/-) mice was reduced in vitro in response to either ADP or thrombin. In vivo, LRP8-hemizygous and LRP8(-/-) mice demonstrated 200% and 68% increased time for carotid occlusion in response to FeCl(3) injury, respectively. Moreover, lipidated apoE3, a ligand for LRP8, inhibited platelet activation in a dose-dependent fashion. This inhibition was markedly attenuated in LRP8(-/-) but not LRP8(+/-) mice and did not result from membrane cholesterol efflux or a nitric oxide dependent pathway. Tail bleeding times were unaffected in both genotypes.
conclusionsOur results suggest that LRP8 is capable of altering thrombosis without affecting normal hemostasis through mechanisms both dependent on and independent of apoE. This suggests a means whereby clot formation could be affected in humans with LRP8 gene variants.
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