Evidence map›Paper›PMID 18706532›Full record

ReviewRespiratory physiology & neurobiology2008

The chemical neuroanatomy of breathing.

George F Alheid, Donald R McCrimmon

Open access · greenAbstract readReview
In one paragraph

Review in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 202 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Revisiting the Role of Serotonin in Sleep-Disordered Breathing.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George F AlheidDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611-3008, USA. gfa@northwestern.edu
Donald R McCrimmon
Northwestern University · US

Funding

Lateral Pontine Neurons in the Control of BreathingR01HL073474 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MC CRIMMON, DONALD R. · 2003 to 2007
$1.8M
PreBotzinger Circuit in Respiratory Rhythm GenerationR01HL072415 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MC CRIMMON, DONALD R. · 2003 to 2007
$1.7M
Central and Peripheral Elements of Respiratory Pattern FormationR01HL088580 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MC CRIMMON, DONALD R. · 2008 to 2011
$1.5M
NHLBI NIH HHS HL 72415NHLBI NIH HHS HL 73474NHLBI NIH HHS HL 80208NHLBI NIH HHS R01 HL072415NHLBI NIH HHS R01 HL073474NHLBI NIH HHS R01 HL088580
6 · The paper itself

Abstract

The chemical neuroanatomy of breathing must ultimately encompass all the various neuronal elements physiologically identified in brainstem respiratory circuits and their apparent aggregation into "compartments" within the medulla and pons. These functionally defined respiratory compartments in the brainstem provide the major source of input to cranial motoneurons controlling the airways, and to spinal motoneurons activating inspiratory and expiratory pump muscles. This review provides an overview of the neuroanatomy of the major compartments comprising brainstem respiratory circuits, and a synopsis of the transmitters used by their constituent respiratory neurons.

Indexed as

RespirationAnimalsHumansRespiratory Center

Identifiers

PMID18706532
PMCPMC2701569
OpenAlexW2072740770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.