ArticleMolecular plant pathology2008
Multi-factor regulation of pectate lyase secretion by Colletotrichum gloeosporioides pathogenic on avocado fruits.
Article in Molecular plant pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 78 citations in OpenAlex.
- Quiescence of postharvest pathogens: a fungal inhibition process or an immune response of the unripe host fruit?The New phytologist · 2026Review
- Establishment of an experimental system to analyse extracellular vesicles during apoplastic fungal pathogenesis.Journal of extracellular biology · 2025Article
- VmPacC-mediated pH regulation of Valsa mali confers to host acidification identified by comparative proteomics analysis.Stress biology · 2023Article
- Organic acid, a virulence factor for pathogenic fungi, causing postharvest decay in fruits.Molecular plant pathology · 2022Review
- Improvement of laccase activity by silencing PacC in Ganoderma lucidum.World journal of microbiology & biotechnology · 2022Article
- Gene deletion and constitutive expression of the pectate lyase gene 1 (MoPL1) lead to diminished virulence of Magnaporthe oryzae.Journal of microbiology (Seoul, Korea) · 2022Article
- The G protein subunit α1, CaGα1, mediates ethylene sensing of mango anthracnose pathogenFrontiers in microbiology · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Article
- The pH-Responsive Transcription Factor PacC Governs Pathogenicity and Ochratoxin A Biosynthesis inFrontiers in microbiology · 2020Article
- Elucidation of the Initial Growth Process and the Infection Mechanism ofMicroorganisms · 2019Article
- The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi.Frontiers in microbiology · 2019Article
- VmPacC Is Required for Acidification and Virulence inFrontiers in microbiology · 2018Article
- How alkalinization drives fungal pathogenicity.PLoS pathogens · 2017Review
- Differential gene expression in tomato fruit and Colletotrichum gloeosporioides during colonization of the RNAi-SlPH tomato line with reduced fruit acidity and higher pH.BMC genomics · 2017Article
- Carbon regulation of environmental pH by secreted small molecules that modulate pathogenicity in phytopathogenic fungi.Molecular plant pathology · 2016Article
- Fungal and host transcriptome analysis of pH-regulated genes during colonization of apple fruits by Penicillium expansum.BMC genomics · 2016Article
- Article
- How Does Host Carbon Concentration Modulate the Lifestyle of Postharvest Pathogens during Colonization?Frontiers in plant science · 2016Review
- The pectate lyase encoded by the pecCl1 gene is an important determinant for the aggressiveness of Colletotrichum lindemuthianum.Journal of microbiology (Seoul, Korea) · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue alkalinization during Colletotrichum gloeosporioides attack enhances the expression of PELB, which encodes pectate lyase (PL), and PL secretion, which is considered essential for full virulence. We studied the regulation of PL secretion by manipulation of C. gloeosporioides PELB. PELB was down-regulated by knocking out PAC1, which encodes the PacC transcription factor that regulates gene products with pH-sensitive activities. We functionally characterized a PACC gene homologue, PAC1, from C. gloeosporioides wild-type (WT) Cg-14 and two independent deletion strains, Deltapac1(372)and Deltapac1(761). Loss-of-function PAC1 mutants showed 85% reduction of PELB transcript expression, delayed PL secretion and dramatically reduced virulence, as detected in infection assays with avocado fruits. In contrast, PELB was up-regulated in the presence of carbon sources such as glucose. When glucose was used as a carbon source in the medium for the WT strain and the Deltapac1 mutant at pH 6.0, PELB transcript expression and PL secretion were activated. Other sugars, such as sucrose and fructose (but not galactose), also activated PELB expression. These results suggest that the pH-regulated response is only part of a multi-factor regulation of PELB, and that sugars are also needed to promote the transition from quiescent to active necrotrophic development by the pathogen.
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