ArticleMolecular plant pathology2008
Involvement of ZFR1 of Fusarium verticillioides in kernel colonization and the regulation of FST1, a putative sugar transporter gene required for fumonisin biosynthesis on maize kernels.
Article in Molecular plant pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 60 citations in OpenAlex.
- Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen.Nucleic acids research · 2026Article
- The Identification, Characterization, and Functional Analysis of the Sugar Transporter Gene Family of the Rice False Smut Pathogen,International journal of molecular sciences · 2024Article
- Genetic Engineering of the Rock InhabitantFrontiers in fungal biology · 2022Article
- Current Perspectives of Biocontrol Agents for Management ofJournal of fungi (Basel, Switzerland) · 2021Review
- Carbon sources to enhance the biosynthesis of useful secondary metabolites in Fusarium verticillioides submerged cultures.World journal of microbiology & biotechnology · 2021Article
- Fusarium oxysporum f. sp. lycopersici CCurrent genetics · 2019Article
- Article
- Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol.Molecular plant pathology · 2017Article
- The novel fungal-specific gene FUG1 has a role in pathogenicity and fumonisin biosynthesis in Fusarium verticillioides.Molecular plant pathology · 2017Article
- Comparative Histological and Transcriptional Analysis of Maize Kernels Infected withFrontiers in plant science · 2017Article
- Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi.Environmental microbiology · 2016Article
- Transcription factor ART1 mediates starch hydrolysis and mycotoxin production in Fusarium graminearum and F. verticillioides.Molecular plant pathology · 2016Article
- Biologically Based Methods for Control of Fumonisin-Producing Fusarium Species and Reduction of the Fumonisins.Frontiers in microbiology · 2016Review
- Lack of the COMPASS Component Ccl1 Reduces H3K4 Trimethylation Levels and Affects Transcription of Secondary Metabolite Genes in Two Plant-PathogenicFrontiers in microbiology · 2016Article
- Transcriptome changes in Fusarium verticillioides caused by mutation in the transporter-like gene FST1.BMC microbiology · 2015Article
- Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides.BMC bioinformatics · 2015Article
- Article
- The dent stage of maize kernels is the most conducive for fumonisin biosynthesis under field conditions.Applied and environmental microbiology · 2011Article
- Regulation of stomatal tropism and infection by light in Cercospora zeae-maydis: evidence for coordinated host/pathogen responses to photoperiod?PLoS pathogens · 2011Article
- The KP4 killer protein gene family.Current genetics · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fumonisins comprise a class of carcinogenic mycotoxins produced by Fusarium verticillioides during colonization of maize kernels. In previous work, we identified ZFR1, which is predicted to encode a Zn(II)2Cys6 zinc finger transcription factor required for fumonisin B(1) (FB(1)) production during growth on kernels. In this study, we characterized the role of ZFR1 in colonizing maize kernels and inducing FB(1) biosynthesis. The ZFR1 deletion strain (Deltazfr1) grew approximately 2.5-fold less than the wild-type on endosperm tissue and a variety of other carbon sources, including glucose and amylopectin. However, the Deltazfr1 strain displayed higher alpha-amylase activity and expression of genes involved in starch saccharification than the wild-type, thus indicating that the reduced growth of the Deltazfr1 strain was not due to inhibition of amylolytic enzymes. In the wild-type strain, expression of six genes encoding putative sugar transporters was significantly greater on endosperm tissue than on germ tissue, and expression of at least three of the six genes was negatively affected by disruption of ZFR1. Intriguingly, disruption of FST1 had no effect on growth, kernel colonization or kernel pH but decreased FB(1) production by approximately 82% on maize kernels. Based on these findings, we hypothesize that ZFR1 controls FB(1) biosynthesis by regulating genes involved in the perception or uptake of carbohydrates.
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