ArticleJournal of cellular and molecular medicine
High-density lipoprotein exerts vasculoprotection via endothelial progenitor cells.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Benefits and harm of niacin and its analog for renal dialysis patients: a systematic review and meta-analysis.International urology and nephrology · 2014Pooled it
- Trial
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- Risk of Ischemic Stroke in Relation toGut and liver · 2024Observational
- HDL and Endothelial Function.Advances in experimental medicine and biology · 2022Article
- Dietary Strategies to Improve Cardiovascular Health: Focus on Increasing High-Density Lipoprotein Functionality.Frontiers in nutrition · 2021Review
- Influence of high density lipoprotein cholesterol levels on circulating monocytic angiogenic cells functions in individuals with type 2 diabetes mellitus.Cardiovascular diabetology · 2018Article
- Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1.Redox biology · 2018Article
- Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.Journal of physiological anthropology · 2017Article
- Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells.Endocrine · 2015Article
- Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease.Journal of geriatric cardiology : JGC · 2014Article
- High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.Nature immunology · 2014Article
- HDL and endothelial protection.British journal of pharmacology · 2013Review
- Apolipoprotein A-I mimetic peptide D-4F promotes human endothelial progenitor cell proliferation, migration, adhesion though eNOS/NO pathway.Molecular biology reports · 2012Article
- Inverse association of plasma level of high-density lipoprotein cholesterol with intracerebral hemorrhage.Journal of lipid research · 2011Article
- Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.The Journal of clinical investigation · 2011Article
- Cholesteryl ester transfer protein and its inhibition.Cellular and molecular life sciences : CMLS · 2010Review
- Synergistic effects of telmisartan and simvastatin on endothelial progenitor cells.Journal of cellular and molecular medicine · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial progenitor cells (EPC) enhance endothelial cell repair, improve endothelial dysfunction and are a predictor for cardiovascular mortality. High-density lipoprotein (HDL) cholesterol levels inversely correlate with cardiovascular events and have vasculoprotective effects. Here we postulate that HDL influences EPC biology. HDL and EPC were isolated according to standard procedures. Differentiation of mononuclear cells into DiLDL/lectin positive cells was enhanced after HDL treatment compared to vehicle. HDL was able to inhibit apoptosis (TUNEL assay, annexin V staining) while proliferation (BrdU incorporation) of early outgrowth colonies after extended cell cultivation (14 days) was increased. Flow chamber experiments revealed an improved adhesion of HDL pre-incubated EPC on human coronary artery endothelial cells (HCAEC) compared to vehicle while HDL treatment of HCAEC prevented adhesion of inflammatory cells. Flow cytometry demonstrated an up-regulation of beta2- and alpha4-integrins on HDL pre-incubated EPC. Blocking experiments revealed a unique role of beta2-integrin in EPC adhesion. Treatment of wild-type mice with recombinant HDL after endothelial denudation resulted in enhanced re-endothelialization compared to vehicle. Finally, in patients with coronary artery disease a correlation between circulating EPC and HDL concentrations was demonstrated. We provide evidence that HDL mediates important vasculoprotective action via the improvement of function of circulating EPC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.