ArticleGenetica2009
Genomic selection: prediction of accuracy and maximisation of long term response.
Article in Genetica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 493 papers.
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Who cites it
493 citing papers in PubMed.
- Combining genomic prediction and multi-trait indices through stochastic simulations: do index type and deployment order affect genetic gain?TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- From family trials to genomic mate allocation: statistical and genomic strategies to accelerate sugarcane genetic improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Genomic selection in timothy (Phleum pratense L.): a comprehensive evaluation of prediction models, multi-trait strategies, and forward validation across Norwegian environments.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Transition from Conventional to Genomic Selection (ssGBLUP) led to improve in accuracy gains and selection decisions in Sahiwal Cattle.Scientific reports · 2026Article
- Nutrigenomics in precision livestock and poultry farming: Enhancing productivity, welfare, and sustainability through gene-tailored diets.Veterinary and animal science · 2026Review
- Better Multi-Breed Genomic Predictions for Tropical Bull Fertility Using a Breed-Adjusted Genomic Relationship Matrix.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Methods to detect selection history in a population under ongoing directional selection.Genetics · 2026Article
- Integrating genomic additive relationship matrices improves the efficiency in diploid banana breeding.Horticulture research · 2026Article
- Targeted allele frequency tuning in breeding populations via alternative optimum contribution selection.Genetics · 2026Article
- Article
- GS-Impute: A neural network framework for accurate imputation of low-density markers in across-population genomic selection.Plant communications · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Recent progress in genomic prediction for Hanwoo cattle and its implications for beef quality: review.Animal bioscience · 2026Article
- Article
- Genomic Prediction Ability for Novel Profitability Traits Using Different Models in Nelore Cattle.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genomic information increases prediction accuracy of behavior traits of Labrador Retrievers used as guide dogs.Genetics, selection, evolution : GSE · 2026Article
- Genetic diversity and population structure analysis of cotton (Gossypium hirsutum L.) genotypes using DArTseq technology.BMC genomics · 2026Article
- Strategies to improve on selection based on estimated breeding values.Genetics, selection, evolution : GSE · 2026Article
- Genomic prediction in insects: a case study on wing morphology traits in the jewel wasp Nasonia vitripennis.G3 (Bethesda, Md.) · 2026Article
- Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Genetic epidemiology · 2026Article
433 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic selection refers to the use of dense markers covering the whole genome to estimate the breeding value of selection candidates for a quantitative trait. This paper considers prediction of breeding value based on a linear combination of the markers. In this case the best estimate of each marker's effect is the expectation of the effect conditional on the data. To calculate this requires a prior distribution of marker effects. If the marker effects are normally distributed with constant variance, BLUP can be used to calculate the estimated effects of the markers and hence the estimated breeding value (EBV). In this case the model is equivalent to a conventional animal model in which the relationship matrix among the animals is estimated from the markers instead of the pedigree. The accuracy of the EBV can approach 1.0 but a very large amount of data is required. An alternative model was investigated in which only some markers have non-zero effects and these effects follow a reflected exponential distribution. In this case the expected effect of a marker is a non-linear function of the data such that apparently small effects are regressed back almost to zero and consequently these markers can be deleted from the model. The accuracy in this case is considerably higher than when marker effects are normally distributed. If genomic selection is practiced for several generations the response declines in a manner that can be predicted from the marker allele frequencies. Genomic selection is likely to lead to a more rapid decline in the selection response than phenotypic selection unless new markers are continually added to the prediction of breeding value. A method to find the optimum index to maximise long term selection response is derived. This index varies the weight given to a marker according to its frequency such that markers where the favourable allele has low frequency receive more weight in the index.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.