ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2008
Eradication of Barrett esophagus with early neoplasia by radiofrequency ablation, with or without endoscopic resection.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Guidelines for surgical treatment of gastroesophageal reflux disease.Surgical endoscopy · 2010Guideline
- Endoscopic treatments for Barrett's esophagus: a systematic review of safety and effectiveness compared to esophagectomy.BMC gastroenterology · 2010Pooled it
- Safety and effectiveness using dexmedetomidine versus propofol TCI sedation during oesophagus interventions: a randomized trial.BMC gastroenterology · 2013Trial
- Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagus.Gastrointestinal endoscopy · 2011Trial
- Durability of radiofrequency ablation in Barrett's esophagus with dysplasia.Gastroenterology · 2011Trial
- A cost-effectiveness modeling study of treatment interventions for stage I to III esophageal squamous cell carcinoma.Cost effectiveness and resource allocation : C/E · 2022Article
- Barrett's esophagus: Review of natural history and comparative efficacy of endoscopic and surgical therapies.World journal of gastrointestinal oncology · 2022Review
- Treatment of high-grade dysplasia and intramucosal carcinoma using radiofrequency ablation or endoscopic mucosal resection + radiofrequency ablation: Meta-analysis and systematic review.World journal of gastrointestinal endoscopy · 2019Article
- Role of endoscopy in early oesophageal cancer.Nature reviews. Gastroenterology & hepatology · 2016Review
- Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2016Article
- Incidence of metachronous visible lesions in patients referred for radiofrequency ablation (RFA) therapy for early Barrett's neoplasia: a single-centre experience.Frontline gastroenterology · 2016Article
- Durability and predictors of successful radiofrequency ablation for Barrett's esophagus.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014Article
- Endoscopic Optical Coherence Tomography for Clinical Gastroenterology.Diagnostics (Basel, Switzerland) · 2014Review
- Epidemiology of esophageal cancer.World journal of gastroenterology · 2013Review
- Evolving changes in the management of early oesophageal adenocarcinoma in a tertiary centre.Irish journal of medical science · 2013Article
- Managing Barrett's esophagus with radiofrequency ablation.Gastroenterology report · 2013Article
- Recurrence of esophageal intestinal metaplasia after endoscopic mucosal resection and radiofrequency ablation of Barrett's esophagus: results from a US Multicenter Consortium.Gastroenterology · 2013Article
- Intestinal metaplasia recurs infrequently in patients successfully treated for Barrett's esophagus with radiofrequency ablation.The American journal of gastroenterology · 2013Article
- Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos).Gastrointestinal endoscopy · 2012Article
- Management strategies of Barrett's esophagus.World journal of gastroenterology · 2012Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiofrequency ablation is safe and effective for complete eradication of nondysplastic Barrett esophagus (BE). The aim was to report the combined results of two published and two ongoing studies on radiofrequency ablation of BE with early neoplasia, as presented at SSAT presidential plenary session DDW 2008.
methodsEnrolled patients had BE < or = 12 cm with early neoplasia. Visible lesions were endoscopically resected. A balloon-based catheter was used for circumferential ablation and an endoscope-based catheter for focal ablation. Ablation was repeated every 2 months until the entire Barrett epithelium was endoscopically and histologically eradicated.
resultsForty-four patients were included (35 men, median age 68 years, median BE 7 cm). Thirty-one patients first underwent endoscopic resection [early cancer (n = 16), high-grade dysplasia (n = 12), low-grade dysplasia (n = 3)]. Worst histology remaining after resection was high-grade (n = 32), low-grade (n = 10), or no (n = 2) dysplasia. After ablation, complete histological eradication of all dysplasia and intestinal metaplasia was achieved in 43 patients (98%). Complications following ablation were mucosal laceration at resection site (n = 3) and transient dysphagia (n = 4). After 21 months of follow-up (interquartile range 10-27), no dysplasia had recurred.
conclusionsRadiofrequency ablation, with or without prior endoscopic resection for visible abnormalities, is effective and safe in eradicating BE and associated neoplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.