ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009
LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Association of lactase 13910 C/T polymorphism with bone mineral density and fracture risk: a meta-analysis.Journal of genetics · 2017Pooled it
- Article
- Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials.PloS one · 2018Article
- Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.European journal of clinical nutrition · 2016Article
- Lactose intolerance: diagnosis, genetic, and clinical factors.Clinical and experimental gastroenterology · 2012Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryLCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density.
introductionThe CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake.
methodsWe studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out.
resultsFrequency of aversion to milk consumption was 20% for CC genotype and 10% for TT + TC genotypes (p = 0.03). The albumin-adjusted serum calcium was 2.325 +/- 0.09 mmol/L for CC genotype and 2.360 +/- 0.16 mmol/L for TT + TC genotypes (p = 0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105 +/- 1.42 vs 0.406 +/- 1.32; p = 0.038), at the total hip (-0.471 +/- 1.08 vs -0.170 +/- 1.09; p = 0.041), and at the Ward's triangle (-0.334 +/- 0.87 vs -0.123 +/- 0.82; p = 0.044).
conclusionLCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.
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