SynthesisEuropean journal of nuclear medicine and molecular imaging2008
FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis.
Synthesis in European journal of nuclear medicine and molecular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Meta-analysis in periprosthetic joint infection: a global bibliometric analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Accuracy of diagnostic tests for prosthetic joint infection: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Evaluation of white cell count and differential in synovial fluid for diagnosing infections after total hip or knee arthroplasty.PloS one · 2014Pooled it
- [American journal of nuclear medicine and molecular imaging · 2026Review
- Managing Nonunions and Fracture-Related Infections-A Quarter Century of Knowledge, and Still Curious: A Narrative Review.Journal of clinical medicine · 2025Review
- Synovial pH, lactate, and glucose as adjunct biomarkers to exclude periprosthetic joint infection in hip and knee arthroplasty: a prospective study.Journal of bone and joint infection · 2025Article
- Imaging in Periprosthetic Joint Infection Diagnosis: A Comprehensive Review.Microorganisms · 2024Review
- Review
- PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals.Diagnostics (Basel, Switzerland) · 2024Review
- Is Imaging Bacteria with PET a Realistic Option or an Illusion?Diagnostics (Basel, Switzerland) · 2023Review
- Infection-specific PET imaging withFrontiers in microbiology · 2023Article
- Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults: A WikiGuidelines Group Consensus Statement.JAMA network open · 2022Article
- Management of periprosthetic knee joint infections: focus on the role of Nuclear Medicine (v2).Orthopedic reviews · 2022Article
- A Systematic Review and Meta-Analysis on the Accuracy of Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography for Diagnosing Periprosthetic Joint Infections.Frontiers in surgery · 2022Review
- Imaging update in arthroplasty.Journal of clinical orthopaedics and trauma · 2021Review
- Pathophysiology and Molecular Imaging of Diabetic Foot Infections.International journal of molecular sciences · 2021Review
- Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections.Scientific reports · 2021Article
- The Role of Imaging Techniques to Define a Peri-Prosthetic Hip and Knee Joint Infection: Multidisciplinary Consensus Statements.Journal of clinical medicine · 2020Article
- Research Progress of [Molecular imaging and biology · 2020Review
- An update on the unparalleled impact of FDG-PET imaging on the day-to-day practice of medicine with emphasis on management of infectious/inflammatory disorders.European journal of nuclear medicine and molecular imaging · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to systematically review and metaanalyze published data on the diagnostic performance of (18)F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in detecting prosthetic hip or knee joint infection.
methodsA systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Two reviewers independently assessed the methodological quality of each study. A metaanalysis of the reported sensitivity and specificity of each study was performed. Subgroup analyses were performed if results of individual studies were heterogeneous.
resultsThe inclusion criteria were met by 11 studies; there was a total sample size of 635 prostheses. Overall, the studies had good methodological quality. Pooled sensitivity and specificity of FDG-PET for the detection of prosthetic hip or knee joint infection were 82.1% (95%CI = 68.0-90.8%) and 86.6% (95%CI = 79.7-91.4%), respectively. Heterogeneity among the results of individual studies was present (I (2) = 68.8%). Diagnostic performance was influenced by type of joint prostheses (hip prostheses vs. knee prostheses) and type of reconstruction method used (filtered back vs. iterative) (p = 0.0164 and p = 0.0235, respectively).
conclusionIn this metaanalysis, overall diagnostic performance of FDG-PET was moderate to high. Caution is warranted, however, because results of individual studies were heterogeneous and could not be fully explored. Future studies should further explore potential causes of heterogeneity and validate the use of FDG-PET for diagnosing prosthetic joint infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.