ArticlePLoS genetics2008
Context differences reveal insulator and activator functions of a Su(Hw) binding region.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hsrω and Other lncRNAs in Neuronal Functions and Disorders inLife (Basel, Switzerland) · 2022Review
- Nuclear receptor corepressors in intellectual disability and autism.Molecular psychiatry · 2020Review
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Investigation of the Developmental Requirements of Drosophila HP1 and Insulator Protein Partner, HIPP1.G3 (Bethesda, Md.) · 2019Article
- Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells ofGenetics · 2018Article
- Deciphering the DNA code for the function of the Drosophila polydactyl zinc finger protein Suppressor of Hairy-wing.Nucleic acids research · 2017Article
- Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex.Molecular and cellular biology · 2015Article
- Neural functions of long noncoding RNAs in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Nucleic acids research · 2014Article
- Surviving an identity crisis: a revised view of chromatin insulators in the genomics era.Biochimica et biophysica acta · 2014Review
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Regulation of gene expression in the genomic context.Computational and structural biotechnology journal · 2014Review
- The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary.Development (Cambridge, England) · 2013Article
- Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary.Nucleic acids research · 2012Article
- Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux.Frontiers in genetics · 2012Article
- Article
- The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis.Developmental biology · 2011Article
- Insulators and promoters: closer than we think.Nature reviews. Genetics · 2010Review
- BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites.PLoS biology · 2008Article
- Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Insulators are DNA elements that divide chromosomes into independent transcriptional domains. The Drosophila genome contains hundreds of binding sites for the Suppressor of Hairy-wing [Su(Hw)] insulator protein, corresponding to locations of the retroviral gypsy insulator and non-gypsy binding regions (BRs). The first non-gypsy BR identified, 1A-2, resides in cytological region 1A. Using a quantitative transgene system, we show that 1A-2 is a composite insulator containing enhancer blocking and facilitator elements. We discovered that 1A-2 separates the yellow (y) gene from a previously unannotated, non-coding RNA gene, named yar for y-achaete (ac) intergenic RNA. The role of 1A-2 was elucidated using homologous recombination to excise these sequences from the natural location, representing the first deletion of any Su(Hw) BR in the genome. Loss of 1A-2 reduced yar RNA accumulation, without affecting mRNA levels from the neighboring y and ac genes. These data indicate that within the 1A region, 1A-2 acts an activator of yar transcription. Taken together, these studies reveal that the properties of 1A-2 are context-dependent, as this element has both insulator and enhancer activities. These findings imply that the function of non-gypsy Su(Hw) BRs depends on the genomic environment, predicting that Su(Hw) BRs represent a diverse collection of genomic regulatory elements.
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