ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment.Behavioral and brain functions : BBF · 2022Pooled it
- Catehol-o-methyltransferase gene Val158met polymorphism as a potential predictor of response to computer-assisted delivery of cognitive-behavioral therapy among cocaine-dependent individuals: Preliminary findings from a randomized controlled trial.The American journal on addictions · 2015Trial
- Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment.Psychopharmacology · 2011Trial
- Disruption of Dopamine Homeostasis by Psychostimulants.Molecular neurobiology · 2026Review
- PGx-BasedCurrent neuropharmacology · 2026Article
- Risk Modeling and Association Pathways Integrating Psychosocial Factors for Drug Misuse in Adolescents and Young Adults: A Machine Learning Approach.European addiction research · 2026Article
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
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- AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance.Computational and structural biotechnology journal · 2021Article
- Catechol-O-methyltransferase and dopamine receptor D4 gene variants: Possible association with substance abuse in Bangladeshi male.PloS one · 2021Article
- Role of placebo effects in pain and neuropsychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Potential Impact ofJournal of cardiovascular development and disease · 2018Article
- Environmental, genetic and epigenetic contributions to cocaine addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- A prospective, longitudinal study to evaluate the clinical utility of a predictive algorithm that detects risk of opioid use disorder.Journal of pain research · 2018Article
- Levamisole: A High Performance Cutting Agent.Academic forensic pathology · 2017Review
- Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs.Molecular neurobiology · 2017Article
- Emergence and Evolution of Hominidae-Specific Coding and Noncoding Genomic Sequences.Genome biology and evolution · 2016Article
- Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.Annals of human genetics · 2015Article
- Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans.Neuroscience letters · 2012Article
- Genetic factors modulating the response to stimulant drugs in humans.Current topics in behavioral neurosciences · 2012Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Dopaminergic brain systems have been documented to have a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. In this study we hypothesize that genetic variation in the COMT gene contributes to increased risk for cocaine dependence. Cocaine-dependent individuals (n=330) and screened unaffected normal controls (n=255) were genotyped for three SNPs in the COMT gene (rs737865, rs4680 (Val158Met), rs165599). All cases and controls were of African descent. Genotype and allele frequencies differed significantly for the Val158Met polymorphism between cases (f(Met)=35%) and controls (f(Met)=27%) (p=0.004; corrected p=0.014; OR 1.44; 95% CI 1.12-1.86). Haplotype analysis showed a significant association for a two-marker haplotype rs737865-Val158Met (p=0.005). Results suggest that variation in COMT increases risk for cocaine dependence. The low enzyme activity 158Met allele or haplotypes containing this variant might have functional effects on dopamine-derived reward processes and cortical functions resulting in increased susceptibility for cocaine dependence. Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.