Unraveling pleiotropic effects of statins: bit by bit, a slow case with perspective.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

1. The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
   Pooled it
2. Statins and secondary prevention of venous thromboembolism: pooled analysis of published observational cohort studies.European heart journal · 2017
   Pooled it
3. Statins, inflammation and deep vein thrombosis: a systematic review.Journal of thrombosis and thrombolysis · 2012
   Pooled it
4. Statins and Venous Thromboembolic Disease - Where are we Now?Current vascular pharmacology · 2024
   Review
5. Therapeutic implications of statins in heart failure with reduced ejection fraction and heart failure with preserved ejection fraction: a review of current literature.F1000Research · 2021
   Review
6. Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral Therapy.International journal of medical sciences · 2021
   Review
7. Potential role of statins in COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
   Review
8. Statin therapy and recurrent venous thromboembolism in the elderly: a prospective cohort study.Scientific reports · 2019
   Observational
9. Statins as a preventative therapy for venous thromboembolism.Cardiovascular diagnosis and therapy · 2017
   Review
10. Antithrombotic Effects of Nur77 and Nor1 Are Mediated Through Upregulating Thrombomodulin Expression in Endothelial Cells.Arteriosclerosis, thrombosis, and vascular biology · 2016
    Article
11. Statin use and bleeding risk during vitamin K antagonist treatment for venous thromboembolism: a multicenter retrospective cohort study.Haematologica · 2015
    Article
12. The association between statin therapy during intensive care unit stay and the incidence of venous thromboembolism: a propensity score-adjusted analysis.BMC pharmacology & toxicology · 2013
    Observational
13. Krüppel-like factor 2 suppression by high glucose as a possible mechanism of diabetic vasculopathy.Korean circulation journal · 2012
    Article
14. High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study.Haematologica · 2011
    Article
15. Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis.Journal of lipid research · 2009
    Article
16. Association of statin use and the risk of recurrent pulmonary embolism in real-world Chinese population.Pulmonary circulation
    Article

Corrections and comments

• Comment on
  Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin.2008

Authors and funding

3 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as