ReviewBlood2009
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.
Review in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Identification of interconnected markers for T-cell acute lymphoblastic leukemia.BioMed research international · 2013Pooled it
- Pooled it
- Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.International journal of oncology · 2018Trial
- Trial
- Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis.Nature communications · 2024Article
- Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia.Cancer cell international · 2021Article
- Gene expression signature predicts relapse in adult patients with cytogenetically normal acute myeloid leukemia.Blood advances · 2021Article
- Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.Scientific reports · 2020Article
- Advances in Genomic Profiling and Risk Stratification in Acute Myeloid Leukemia.Seminars in oncology nursing · 2019Review
- Review
- PRECOG: a tool for automated extraction and visualization of fitness components in microbial growth phenomics.BMC bioinformatics · 2016Article
- Acute myeloid leukemia: advancing clinical trials and promising therapeutics.Expert review of hematology · 2016Review
- Review
- Detection of mutations in myeloid malignancies through paired-sample analysis of microdroplet-PCR deep sequencing data.The Journal of molecular diagnostics : JMD · 2014Article
- A program to identify prognostic and predictive gene signatures.BMC research notes · 2014Article
- ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.PloS one · 2014Article
- Article
- MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia.PloS one · 2013Article
- Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.Oncotarget · 2012Article
- Kit inhibitor APcK110 extends survival in an AML xenograft mouse model.Investigational new drugs · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The past decade has shown a marked increase in the use of high-throughput assays in clinical research into human cancer, including acute myeloid leukemia (AML). In particular, genome-wide gene expression profiling (GEP) using DNA microarrays has been extensively used for improved understanding of the diagnosis, prognosis, and pathobiology of this heterogeneous disease. This review discusses the progress that has been made, places the technologic limitations in perspective, and highlights promising future avenues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.