ArticleJournal of leukocyte biology2008
Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection.
Article in Journal of leukocyte biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Innate immune recognition ofCell surface (Amsterdam, Netherlands) · 2025Review
- Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization.Frontiers in immunology · 2020Article
- Review
- Article
- IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice.JCI insight · 2017Article
- CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture.PloS one · 2014Article
- Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy.PLoS neglected tropical diseases · 2014Article
- Modulation of cell death by M. tuberculosis as a strategy for pathogen survival.Clinical & developmental immunology · 2011Article
- Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.The Journal of experimental medicine · 2010Article
- Dendritic cells in the pathogenesis of sarcoidosis.American journal of respiratory cell and molecular biology · 2010Review
- Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis.Molecular immunology · 2009Article
- Spotlight on Mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge?EMBO molecular medicine · 2009Review
- Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.PLoS pathogens · 2008Article
- Microarray analysis of the in vitro granulomatous response to Mycobacterium tuberculosis H37Ra.Colombia medica (Cali, Colombia)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this study, the early innate cytokine and chemokine response of murine dendritic cells (DCs) and macrophages to Mycobacterium tuberculosis infection was compared. The findings indicate a dissimilar gene expression pattern between the two cell types. The expression of IL-12 and IL-23, important for promoting Th1 and Th17 cells, respectively, was up-regulated only in DCs. In addition, expression of CCL1 and CCL17, which are important in recruitment of T regulatory cells, was DC-specific, as was the expression of the immunosuppressive cytokine IL-10. Macrophages, in contrast, exhibited enhanced expression for CCL2 and CXCL10, chemokines that recruit cells to sites of inflammation, and for mycobactericidal molecules NO synthase 2 and TNF. Together, the findings suggest that a component of the innate DC response is not only programmed toward Th1 priming but is also for controlling the magnitude of the Th1 response, and part of the macrophage response is intended for recruiting cells to the lung and for mycobactericidal functions.
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