ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis-related phenotypes.Physiology & behavior · 2023Article
- Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats.Stress (Amsterdam, Netherlands) · 2023Article
- Reprogramming of glucocorticoid receptor function by hypoxia.EMBO reports · 2022Article
- Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development.Frontiers in pediatrics · 2021Article
- Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide.Physiological reports · 2021Article
- Corticosterone, Adrenal, and the Pituitary-Gonadal Axis in Neonatal Rats: Effect of Maternal Separation and Hypoxia.Endocrinology · 2020Article
- T-cell Receptor Excision Circles in Newborns with Heart Defects.Pediatric cardiology · 2020Article
- The effects of flutamide on the neonatal rat hypothalamic-pituitary-adrenal and gonadal axes in response to hypoxia.Physiological reports · 2019Article
- Effect of a melanocortin type 2 receptor (MC2R) antagonist on the corticosterone response to hypoxia and ACTH stimulation in the neonatal rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Sex differences in adult rat insulin and glucose responses to arginine: programming effects of neonatal separation, hypoxia, and hypothermia.Physiological reports · 2016Article
- Effect of Novel Melanocortin Type 2 Receptor Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland In Vivo and In Vitro.Frontiers in endocrinology · 2016Article
- Pharmacological stimulation of hypoxia inducible factor-1α facilitates the corticosterone response to a mild acute stressor.Neuroscience letters · 2015Article
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Adrenocortical control in the neonatal rat: ACTH- and cAMP-independent corticosterone production during hypoxia.Physiological reports · 2013Article
- Article
- Age and sex differences in the ventilatory response to hypoxia and hypercapnia in awake neonatal, pre-pubertal and young adult rats.Respiratory physiology & neurobiology · 2012Article
- Effect of animal facility construction on basal hypothalamic-pituitary-adrenal and renin-aldosterone activity in the rat.Endocrinology · 2011Article
- Effect of high-dose total body irradiation on ACTH, corticosterone, and catecholamines in the rat.Translational research : the journal of laboratory and clinical medicine · 2011Article
- Stress and adrenergic function: HIF1α, a potential regulatory switch.Cellular and molecular neurobiology · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acute episodes of severe hypoxia are among the most common stressors in neonates. An understanding of the development of the physiological response to acute hypoxia will help improve clinical interventions. The present study measured ACTH and corticosterone responses to acute, severe hypoxia (8% inspired O(2) for 4 h) in neonatal rats at postnatal days (PD) 2, 5, and 8. Expression of specific hypothalamic, anterior pituitary, and adrenocortical mRNAs was assessed by real-time PCR, and expression of specific proteins in isolated adrenal mitochondria from adrenal zona fascisulata/reticularis was assessed by immunoblot analyses. Oxygen saturation, heart rate, and body temperature were also measured. Exposure to 8% O(2) for as little as 1 h elicited an increase in plasma corticosterone in all age groups studied, with PD2 pups showing the greatest response ( approximately 3 times greater than PD8 pups). Interestingly, the ACTH response to hypoxia was absent in PD2 pups, while plasma ACTH nearly tripled in PD8 pups. Analysis of adrenal mRNA expression revealed a hypoxia-induced increase in Ldlr mRNA at PD2, while both Ldlr and Star mRNA were increased at PD8. Acute hypoxia decreased arterial O(2) saturation (SPo(2)) to approximately 80% and also decreased body temperature by 5-6 degrees C. The hypoxic thermal response may contribute to the ACTH and corticosterone response to decreases in oxygen. The present data describe a developmentally regulated, differential corticosterone response to acute hypoxia, shifting from ACTH independence in early life (PD2) to ACTH dependence less than 1 wk later (PD8).
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