ArticleJournal of the American Society for Mass Spectrometry2008
A study of phospholipids by ion mobility TOFMS.
Article in Journal of the American Society for Mass Spectrometry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- An Untargeted Lipidomics Workflow Incorporating High-Resolution Demultiplexing (HRdm) Drift Tube Ion Mobility-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024Article
- High-throughput analysis of lipidomic phenotypes of methicillin-resistant Staphylococcus aureus by coupling in situ 96-well cultivation and HILIC-ion mobility-mass spectrometry.Analytical and bioanalytical chemistry · 2023Article
- Separation of Isobaric Lipids in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions.Journal of the American Society for Mass Spectrometry · 2023Article
- Article
- Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry.Journal of lipid research · 2019Article
- New Frontiers in Lipidomics Analyses using Structurally Selective Ion Mobility-Mass Spectrometry.Trends in analytical chemistry : TRAC · 2019Article
- Ion mobility conformational lipid atlas for high confidence lipidomics.Nature communications · 2019Article
- Large-Scale Structural Characterization of Drug and Drug-Like Compounds by High-Throughput Ion Mobility-Mass Spectrometry.Analytical chemistry · 2017Article
- Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles.Journal of the American Society for Mass Spectrometry · 2017Article
- Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics.Journal of lipid research · 2017Article
- Probing the Relationship Between Detected Ion Intensity, Laser Fluence, and Beam Profile in Thin Film and Tissue in MALDI MSI.Journal of the American Society for Mass Spectrometry · 2016Article
- Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry.Analytical chemistry · 2016Article
- Applications of mass spectrometry for cellular lipid analysis.Molecular bioSystems · 2015Review
- Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification.Analytical chemistry · 2015Article
- Lipidomic analysis of cerebrospinal fluid by mass spectrometry-based methods.Journal of inherited metabolic disease · 2015Review
- Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry.Trends in analytical chemistry : TRAC · 2014Article
- Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry.Journal of lipid research · 2014Article
- MALDI-Ion Mobility Mass Spectrometry of Lipids in Negative Ion Mode.Analytical methods : advancing methods and applications · 2014Article
- MALDI/post ionization-ion mobility mass spectrometry of noncovalent complexes of dopamine receptors' epitopes.Journal of proteome research · 2013Article
- Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.Journal of lipid research · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Combining matrix-assisted laser desorption/ionization (MALDI) mass spectrometry with ion mobility (IM) results in the fast sorting of biomolecules in complex mixtures along trend lines. In this two-dimensional (2D) analysis of biological families, lipids, peptides, and nucleotides are separated from each other by differences in their ion mobility drift times in a timescale of hundreds of microseconds. Molecular ions of similar chemical type fall along trend lines when plotted in 2D plots of ion mobility drift time as a function of m/z. In this study, MALDI-IM MS is used to analyze species from all of the major phospholipid classes. Complex samples, including tissue extracts and sections, were probed to demonstrate the effects that radyl chain length, degree of unsaturation, and class/head group have upon an ion's cross section in the gas phase. We illustrate how these changes can be used to identify individual lipid species in complex mixtures, as well as the effects of cationization on ion cross section and ionization efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.