ArticleNeurobiology of aging2010
A comparative study to screen dementia and APOE genotypes in an ageing East African population.
Article in Neurobiology of aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Epidemiology of neurodegenerative diseases in the East African region: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Epidemiology of neurodegenerative diseases in sub-Saharan Africa: a systematic review.BMC public health · 2014Pooled it
- Genetics and environmental determinants of Alzheimer's disease and related dementias in older Africans: a narrative review.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Review
- The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Challenges in evaluating cognitive impairment in diabetics in the Democratic Republic of the Congo.Dementia & neuropsychologia · 2024Article
- A global view of the genetic basis of Alzheimer disease.Nature reviews. Neurology · 2023Review
- Dementia in Africa: Current evidence, knowledge gaps, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Apolipoprotein E Genetic Variation and Its Association With Cognitive Function in Rural-Dwelling Older South Africans.Frontiers in genetics · 2021Article
- 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.Ageing research reviews · 2018Review
- Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging.Dementia and neurocognitive disorders · 2016Review
- Neurogenomics in Africa: Perspectives, progress, possibilities and priorities.Journal of the neurological sciences · 2016Review
- APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.PloS one · 2016Article
- APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba.International psychogeriatrics · 2014Article
- Exercise, APOE genotype, and the evolution of the human lifespan.Trends in neurosciences · 2014Review
- Epidemiology of Dementia among the Elderly in Sub-Saharan Africa.International journal of Alzheimer's disease · 2014Review
- Development and community-based validation of the IDEA study Instrumental Activities of Daily Living (IDEA-IADL) questionnaire.Global health action · 2014Article
- Dementia prevalence estimates in sub-Saharan Africa: comparison of two diagnostic criteria.Global health action · 2013Article
- Hygiene and the world distribution of Alzheimer's disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden.Evolution, medicine, and public health · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.