ReviewNeuroscience and biobehavioral reviews2009
Mechanisms underlying altered mood and cardiovascular dysfunction: the value of neurobiological and behavioral research with animal models.
Review in Neuroscience and biobehavioral reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Depression with Subclinical Coronary Atherosclerosis: a Systematic Review.Journal of cardiovascular translational research · 2021Pooled it
- Mouse Testing Methods in Psychoneuroimmunology: Measuring Behavioral Responses.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Pre-pregnancy stress induces maternal vascular dysfunction during pregnancy and postpartum.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.Psychopharmacology · 2022Review
- The higher levels of self-reported satisfaction, the lower risk of depressive symptoms: Evidence from a nationwide cross-sectional study in China.Frontiers in medicine · 2022Article
- Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats.Neuroscience bulletin · 2021Article
- Alzheimer and depressive cognitive-like behaviors in male and female rats: A new method for exposure to ambient air pollution.MethodsX · 2019Article
- Antidepressant and anxiolytic effects of the proprietary Chinese medicine Shexiang Baoxin pill in mice with chronic unpredictable mild stress.Journal of food and drug analysis · 2019Article
- Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.JACC. Basic to translational science · 2018Article
- Cardiac and behavioral effects of social isolation and experimental manipulation of autonomic balance.Autonomic neuroscience : basic & clinical · 2018Article
- Overactive Bladder is a Distress Symptom in Heart Failure.International neurourology journal · 2018Article
- Does chronic disease influence susceptibility to the effects of air pollution on depressive symptoms in China?International journal of mental health systems · 2018Article
- Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Opinion: "Heart Rate Variability, Health and Well-Being: A Systems Perspective" Research Topic.Frontiers in public health · 2017Article
- Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type.Frontiers in physiology · 2016Review
- Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents.Frontiers in psychiatry · 2016Review
- Role of peripheral vascular resistance for the association between major depression and cardiovascular disease.Journal of cardiovascular pharmacology · 2015Review
- Loneliness: clinical import and interventions.Perspectives on psychological science : a journal of the Association for Psychological Science · 2015Review
- Identification of hypertensive patients with dominant affective temperaments might improve the psychopathological and cardiovascular risk stratification: a pilot, case-control study.Annals of general psychiatry · 2015Article
- Effects of curcumin on glucose metabolism in the brains of rats subjected to chronic unpredictable stress: a 18 F-FDG micro-PET study.BMC complementary and alternative medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A bidirectional association between mood disorders and cardiovascular diseases has been described in humans, yet the precise neurobiological mechanisms that underlie this association are not fully understood. This article is focused on neurobiological processes and mediators in mood and cardiovascular disorders, with an emphasis on common mechanisms including stressor reactivity, neuroendocrine and neurohumoral changes, immune alterations, autonomic and cardiovascular dysregulation, and central neurotransmitter and neuropeptide dysfunction. A discussion of the utility of experimental investigations with rodent models, including those in rats and prairie voles (Microtus ochrogaster), is presented. Specific studies using these models are reviewed, focusing on the analysis of behavioral, physiological and neural mechanisms underlying depressive disorders and cardiovascular disease. Considered in combination with studies using human samples, the investigation of mechanisms underlying depressive behaviors and cardiovascular regulation using animal models will enhance our understanding of the association of depression and cardiovascular disease, and will promote the development of improved interventions for individuals with these detrimental disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.