ArticleJournal of virology1991
Activation of the c-ski oncogene by overexpression.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
- Ski promotes proliferation and inhibits apoptosis in fibroblasts under high-glucose conditions via the FoxO1 pathway.Cell proliferation · 2021Article
- Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.Nucleic acids research · 2018Article
- c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion.Molecular oncology · 2013Article
- Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer.Virology · 2013Article
- Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.Journal of cellular physiology · 2012Article
- SnoN in mammalian development, function and diseases.Current opinion in pharmacology · 2010Review
- SnoN: bridging neurobiology and cancer biology.Current molecular medicine · 2010Article
- The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.The Journal of biological chemistry · 2009Article
- Oncogene and tumour suppressor: the two faces of SnoN.The EMBO journal · 2009Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Ski and SnoN, potent negative regulators of TGF-beta signaling.Cell research · 2009Review
- Dual role of SnoN in mammalian tumorigenesis.Molecular and cellular biology · 2007Article
- Article
- The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis.Oncogene · 2005Article
- Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma.Virchows Archiv : an international journal of pathology · 2004Article
- Ski negatively regulates erythroid differentiation through its interaction with GATA1.Molecular and cellular biology · 2004Article
- Article
- Review
- Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.Genes & development · 2001Article
- Interferon regulatory factor 4 contributes to transformation of v-Rel-expressing fibroblasts.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The v-ski oncogene is a truncated version of the cellular proto-oncogene, c-ski, and lacks sequences coding for both the N- and C-terminal ends of the c-ski protein. In the region of overlap, v-ski and c-ski differ by only one amino acid. To determine whether these differences underlie v-ski's oncogenic activation, we have cloned cDNAs for several alternatively spliced c-ski mRNAs and introduced these cDNAs into replication-competent retroviral vectors. The biological activities of these c-ski constructs have been compared with those of v-ski. We found that all c-ski gene products, when expressed at high levels from the promoter in the retroviral long terminal repeat, can induce morphological transformation, anchorage independence, and muscle differentiation in avian cells. Cells that are susceptible to ski-induced transformation and myogenesis normally express endogenous c-ski at low levels. Thus, it appears that overexpression of ski is sufficient for oncogenic and myogenic activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.