ReviewCanadian journal of gastroenterology = Journal canadien de gastroenterologie2008
Primary sclerosing cholangitis.
Review in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Ursodiol and colorectal cancer or dysplasia risk in primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis.Digestive diseases and sciences · 2013Pooled it
- Bile acids for primary sclerosing cholangitis.The Cochrane database of systematic reviews · 2011Pooled it
- Glucocorticosteroids for primary sclerosing cholangitis.The Cochrane database of systematic reviews · 2010Pooled it
- The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.The American journal of gastroenterology · 2011Trial
- The predictors of the presence of varices in patients with primary sclerosing cholangitis.Hepatology (Baltimore, Md.) · 2010Trial
- High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis.Hepatology (Baltimore, Md.) · 2009Trial
- Disease severity prognostication in primary sclerosing cholangitis: a validation of the Anali scores and comparison with the potential functional stricture.European radiology · 2024Article
- Still elusive: Developments in the accurate diagnosis of indeterminate biliary strictures.World journal of gastrointestinal endoscopy · 2024Review
- Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report.Radiology case reports · 2023Article
- Healthcare Utilization Among Patients Hospitalized With Gastrointestinal Diseases in the United States.Gastro hep advances · 2023Article
- The Role of Sex in Acute and Chronic Liver Damage.International journal of molecular sciences · 2022Review
- The NOD Mouse Beyond Autoimmune Diabetes.Frontiers in immunology · 2022Review
- Rodent models of cholestatic liver disease: A practical guide for translational research.Liver international : official journal of the International Association for the Study of the Liver · 2021Review
- Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.Journal of clinical medicine research · 2019Review
- Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran.Hepatitis monthly · 2015Article
- Frequency and risk factors of primary sclerosing cholangitis among patients with inflammatory bowel disease in North-East of Iran.Gastroenterology and hepatology from bed to bench · 2015Article
- A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis.Journal of feline medicine and surgery · 2014Article
- Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model.Digestive diseases and sciences · 2013Article
- T helper 17 cells in autoimmune liver diseases.Clinical & developmental immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy. PSC primarily affects young and middle-aged men, often in association with underlying inflammatory bowel disease. The etiology of PSC includes immune-mediated components and elements of undefined nature. A cholestatic picture of liver biochemistries with elevations in serum alkaline phosphatase, nonspecific autoantibodies such as perinuclear antineutrophilic antibody, antinuclear antibodies and smooth muscle antibodies, and diffuse multifocal biliary strictures, resulting in a 'beaded' appearance on radiographic studies, are the hallmarks of the disease. No effective medical therapy is currently available, although clinical studies are in progress. Ursodeoxycholic acid at high doses (28 mg/kg/day to 30 mg/kg/day) is the most promising agent but is unproven so far. Liver transplantation is currently the only life-extending therapy for patients with end-stage disease, although recurrent disease can be observed in the transplanted liver. The multiple complications of PSC include pruritus, fatigue, vitamin deficiencies, metabolic bone disease, peristomal varices, bacterial cholangitis, dominant biliary strictures, gallbladder stones and polyps, and malignancy, particularly cholangiocarcinoma, which is the most lethal complication of PSC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.