Evidence map›Paper›PMID 18701939›Full record

ArticleDrug discovery today. Disease mechanisms2007

Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.

Eric R Gross, Garrett J Gross

Open access · greenAbstract read
In one paragraph

Article in Drug discovery today. Disease mechanisms, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

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  11. Targeting of adenosine receptors in ischemia-reperfusion injury.Expert opinion on therapeutic targets · 2011
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eric R GrossMedical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, WI 53226.
Garrett J Gross
Medical College of Wisconsin · US

Funding

Cytochrome P450 Eicosanoids and Myocardial InjuryR37HL074314 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GROSS, GARRETT JOHN · 2003 to 2012
$3.7M
EFFECTS OF DRUGS UPON MYOCARDIAL HYPOXIAR01HL008311 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GROSS, GARRETT JOHN · 1985 to 2009
$2.7M
NHLBI NIH HHS R01 HL008311NHLBI NIH HHS R37 HL074314
6 · The paper itself

Abstract

Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress. Hence, this review provides an update on IPC, including general and molecular mechanisms responsible for IPC and the effects of IPC in models of aging or disease. A summary of therapeutics shown to possess efficacy in preclinical and clinical trials and future directions of studies regarding cardiac IPC are also discussed.

Identifiers

PMID18701939
PMCPMC2515553
OpenAlexW2020474832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.