ArticleJournal of neurophysiology2008
Urine stimulation activates BK channels in mouse vomeronasal neurons.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cyclophosphamide has Long-Term Effects on Proliferation in Olfactory Epithelia.Chemical senses · 2020Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.Frontiers in physiology · 2017Review
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- GnRH suppresses excitability of visual processing neurons in the optic tectum.Journal of neurophysiology · 2015Article
- TRICK or TRP? What Trpc2(-/-) mice tell us about vomeronasal organ mediated innate behaviors.Frontiers in neuroscience · 2015Article
- Article
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Serotonin modulates the population activity profile of olfactory bulb external tufted cells.Journal of neurophysiology · 2012Article
- Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons.Nature communications · 2011Article
- Interaction of arachidonic acid with electrogenic properties of mouse chemosensory neurons.European journal of medical research · 2010Article
- The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.BMC neuroscience · 2010Article
- Odors activate dual pathways, a TRPC2 and a AA-dependent pathway, in mouse vomeronasal neurons.American journal of physiology. Cell physiology · 2010Article
- Calcium-activated chloride current amplifies the response to urine in mouse vomeronasal sensory neurons.The Journal of general physiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most odor responses in mouse vomeronasal neurons are mediated by the phospholipase C (PLC) pathway, activation of which elevates diacylglycerol (DAG). Lucas et al. showed that DAG activates transient receptor potential channels, subfamily C, member 2 (TRPC2), resulting in a depolarizing Ca2+ influx. DAG can be subsequently converted to arachidonic acid (AA) by a DAG lipase, the role of which remains largely unknown. In this study, we found that urine stimulation of vomeronasal neurons activated large-conductance Ca2+-activated K+ (BK) channels via AA production. Using isolated neurons, we demonstrated that repetitive applications of AA potentiated a K+ current that required a Ca2+ influx and was sensitive to specific BK blockers. Using immunocytochemistry, we found that BK channels are present in vomeronasal neurons with labeling on the soma and heavy labeling on the dendrite with a BK channel antibody. We examined the role of these BK channels in regulating neuronal firing when the neuron was activated by membrane depolarization or urine. Contrary to a recent report, our data suggest that BK channels contribute to adaptation of urine/odor responses because the inhibition of BK channels during urine stimulation promoted repetitive firing. These data strongly support the hypothesis that AA mediates an inhibitory pathway through BK channels, a possible mechanism for odor adaptation in vomeronasal neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.