ArticleJournal of clinical microbiology2008
Epidemic keratoconjunctivitis due to the novel hexon-chimeric-intermediate 22,37/H8 human adenovirus.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Evaluation of factors relating to the development of multiple subepithelial corneal infiltrates of adenoviral keratoconjunctivitis using categorical data analysis program.Japanese journal of ophthalmology · 2025Article
- Broad sialic acid usage amongst species D human adenovirus.Npj viruses · 2023Article
- First Record of HAdV-D20 Among Keratoconjunctivitis Patients in Iraq.Reports of biochemistry & molecular biology · 2022Article
- Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis.Progress in retinal and eye research · 2020Review
- Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism.Emerging microbes & infections · 2020Article
- Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.MMWR. Morbidity and mortality weekly report · 2018Article
- Molecular epidemiology of human adenovirus infections in Denmark, 2011-2016.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Article
- Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection.Mucosal immunology · 2016Article
- Human adenovirus: Viral pathogen with increasing importance.European journal of microbiology & immunology · 2014Article
- Overreliance on the hexon gene, leading to misclassification of human adenoviruses.Journal of virology · 2012Article
- Real-time qualitative PCR for 57 human adenovirus types from multiple specimen sources.Journal of clinical microbiology · 2012Article
- Review
- Molecular evolution of human species D adenoviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Complete genome analysis of a novel intertypic recombinant human adenovirus causing epidemic keratoconjunctivitis in Japan.Journal of clinical microbiology · 2011Article
- Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan.Molecular vision · 2011Article
- Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene.Journal of virology · 2009Article
- Spread of epidemic keratoconjunctivitis due to a novel serotype of human adenovirus in Japan.Journal of clinical microbiology · 2009Article
- Article
- Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate.Virus research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a 2-month period in 2003, we encountered an outbreak of epidemic keratoconjunctivitis (EKC) in Japan. We detected 67 human adenoviruses (HAdVs) by PCR from eye swabs of patients with EKC at five eye clinics in different parts of Japan. Forty-one of the 67 HAdV DNAs from the swabs were identified as HAdV-37 by phylogenetic analysis using a partial hexon gene sequence. When the restriction patterns of these viral genomes were compared with that of the HAdV-37 prototype strain, one isolate showed a never-before-seen restriction pattern. Within 1 year, we encountered three more EKC cases caused by a genetically identical virus: two nosocomial infections at two different university hospitals and a sporadic infection at an eye clinic. We determined the nucleotide sequences of the full-length hexon and fiber genes of these isolates and compared them to those of the 51 prototype strains. Surprisingly, the sequence of the hexon (epsilon determinant) loop-1 and -2 regions showed the highest nucleotide identity with HAdV-22, a rare EKC isolate. However, the nucleotide sequence of the fiber gene was identical to that of the HAdV-8 prototype strain. 22 We propose that this virus is a new hexon-chimeric intermediate HAdV-22,37/H8, and may be an etiological agent of EKC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.