ArticleDevelopment (Cambridge, England)2008
A new family of transcription factors.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor.Current biology : CB · 2022Article
- CRISPR Toolbox for Genome Editing inFrontiers in cell and developmental biology · 2021Article
- Cyclic AMP induction of Dictyostelium prespore gene expression requires autophagy.Developmental biology · 2019Article
- The transcription factor Spores Absent A is a PKA dependent inducer of Dictyostelium sporulation.Scientific reports · 2018Article
- Prunus transcription factors: breeding perspectives.Frontiers in plant science · 2015Review
- Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation.PloS one · 2012Article
- Characterization of the Dictyostelium homolog of chromatin binding protein DET1 suggests a conserved pathway regulating cell type specification and developmental plasticity.Eukaryotic cell · 2011Article
- Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki.Molecular biology and evolution · 2011Article
- Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.Genome biology · 2011Article
- Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity.Genome biology and evolution · 2010Article
- Transcriptomic changes arising during light-induced sporulation in Physarum polycephalum.BMC genomics · 2010Article
- Identification of a target for CudA, the transcription factor which directs formation of the Dictyostelium tip organiser.The International journal of developmental biology · 2010Article
- Synergy between two transcription factors directs gene expression in Dictyostelium tip-organiser cells.The International journal of developmental biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
CudA, a nuclear protein required for Dictyostelium prespore-specific gene expression, binds in vivo to the promoter of the cotC prespore gene. A 14 nucleotide region of the cotC promoter binds CudA in vitro and ECudA, an Entamoeba CudA homologue, also binds to this site. The CudA and ECudA DNA-binding sites contain a dyad and, consistent with a symmetrical binding site, CudA forms a homodimer in the yeast two-hybrid system. Mutation of CudA binding sites within the cotC promoter reduces expression from cotC in prespore cells. The CudA and ECudA proteins share a 120 amino acid core of homology, and clustered point mutations introduced into two highly conserved motifs within the ECudA core region decrease its specific DNA binding in vitro. This region, the presumptive DNA-binding domain, is similar in sequence to domains in two Arabidopsis proteins and one Oryza protein. Significantly, these are the only proteins in the two plant species that contain an SH2 domain. Such a structure, with a DNA-binding domain located upstream of an SH2 domain, suggests that the plant proteins are orthologous to metazoan STATs. Consistent with this notion, the DNA sequence of the CudA half site, GAA, is identical to metazoan STAT half sites, although the relative positions of the two halves of the dyad are reversed. These results define a hitherto unrecognised class of transcription factors and suggest a model for the evolution of STATs and their DNA-binding sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.