SynthesisRheumatology (Oxford, England)2008
A systematic comparison of fatigue levels in systemic sclerosis with general population, cancer and rheumatic disease samples.
Synthesis in Rheumatology (Oxford, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Pain and fatigue in systemic sclerosis: Practical strategies for non-pharmacological management.Journal of scleroderma and related disorders · 2025Review
- Kinesiophobia in Systemic Sclerosis: Relationship With Functional Status, Pulmonary Fibrosis, Depression, and Other Clinical Parameters.Journal of clinical medicine research · 2025Article
- Early, integrated systemic sclerosis palliative care for patients and their caregivers: description of a new model of care.Rheumatology advances in practice · 2025Article
- Emotional intelligence: a novel predictor of quality of life in patients with systemic sclerosis.Rheumatology international · 2024Article
- Effects of a telerehabilitation-based exercise program in patients with systemic sclerosis.Zeitschrift fur Rheumatologie · 2024Article
- Minimal Clinically Important Differences (MCID) for the Functional Assessment of Chronic Illness Therapy Fatigue Scale in Patients with Systemic Sclerosis.International journal of environmental research and public health · 2022Article
- Onset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in pediatrics · 2019Article
- Comparison of Level of Fatigue and Disease Correlates in Patients With Rheumatoid Arthritis and Systemic Sclerosis.Archives of rheumatology · 2018Article
- Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire.The Journal of rheumatology · 2018Article
- Association between cortisol levels and pain threshold in systemic sclerosis and major depression.Rheumatology international · 2018Observational
- Functional disability and other health-related quality-of-life domains: points to consider for clinical trials in systemic sclerosis.Rheumatology (Oxford, England) · 2017Review
- The Turkish Version of Multidimensional Assessment of Fatigue and Fatigue Severity Scale is Reproducible and Correlated With Other Outcome Measures in Patients With Systemic Sclerosis.Archives of rheumatology · 2016Article
- Sexual dysfunction in married women with Systemic Sclerosis.The Pan African medical journal · 2014Article
- Article
- Sleep quality in patients with systemic sclerosis: relationship between the clinical variables, depressive symptoms, functional status, and the quality of life.Rheumatology international · 2013Article
- In systemic sclerosis, anxiety and depression assessed by hospital anxiety depression scale are independently associated with disability and psychological factors.BioMed research international · 2013Article
- Predictors of health-related quality of life and fatigue in systemic sclerosis: evaluation of the EuroQol-5D and FACIT-F assessment tools.Clinical rheumatology · 2012Article
- Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort.PloS one · 2011Article
- Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine.The Journal of rheumatology · 2009Article
- New directions for patient-centred care in scleroderma: the Scleroderma Patient-centred Intervention Network (SPIN).Clinical and experimental rheumatologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThere are no studies of fatigue levels in patients with SSc. The objective of this study was to compare fatigue in SSc to general population samples and patients with rheumatic diseases and cancer, where fatigue has been researched extensively.
methodsSSc patients completed the General Fatigue Index (GFI) of the Multidimensional Fatigue Inventory. A systematic review was conducted to select comparison samples. Mean GFI scores from SSc patients were compared with mean scores from comparison samples with t-tests and Bonferroni corrections (family-wise P < 0.05).
resultsA total of 106 SSc patients were sampled (97 females; 28 diffuse SSc; 11.9 +/- 7.9 yrs since diagnosis). Based on comparisons from the systematic review, mean GFI scores in SSc (13.3 +/- 4.6) were significantly higher (greater fatigue; P < 0.05) than in two large population samples (8.7 and 9.6) and than in two samples of cancer patients in remission (9.4 and 10.0). Scores for the SSc sample were significantly lower (less fatigue) compared with two samples of cancer patients in palliative care (16.8 and 17.0). SSc GFI scores were similar to scores from patients with RA (13.4), AS (13.0) and SLE (13.1) and to scores from six studies of cancer patients in active treatment (11.1-13.5).
conclusionsThe high levels of fatigue reported in SSc were similar to patients with varying types and treatment stages of cancer and patients with other rheumatic diseases when assessed with the GFI, demonstrating that fatigue warrants greater attention in SSc.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.