ArticleCancer research2008
Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Cumulative evidence for relationships between multiple variants of HNF1B and the risk of prostate and endometrial cancers.BMC medical genetics · 2018Pooled it
- Assessment of association between common variants at 17q12 and prostate cancer risk-evidence from Serbian population and meta--analysis.Clinical and translational science · 2014Pooled it
- Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation.Oncogene · 2022Article
- Hepatocyte nuclear factor 1 beta: A perspective in cancer.Cancer medicine · 2021Review
- Gene-environment interactions in case-control studies with silent disease.Genetic epidemiology · 2018Article
- Connecting myelin-related and synaptic dysfunction in schizophrenia with SNP-rich gene expression hubs.Scientific reports · 2017Article
- Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites.Human mutation · 2016Article
- Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population.Journal of cancer research and clinical oncology · 2014Article
- Article
- Genetic variations of α -methylacyl-CoA racemase are associated with sporadic prostate cancer risk in ethnically homogenous Koreans.BioMed research international · 2013Article
- Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy.PloS one · 2013Article
- Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes.PloS one · 2012Article
- Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Genome-wide linkage scan for prostate cancer susceptibility in Finland: evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22.International journal of cancer · 2011Article
- Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population.Chinese journal of cancer · 2011Article
- Genetic Variants in MMP9 and TCF2 Contribute to Susceptibility to Lung Cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2011Article
- Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a Caucasian cohort.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
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- Number of prostate cancer risk alleles may identify possibly 'insignificant' disease.BJU international · 2010Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In a recent genome-wide association study by Gudmundsson and colleagues, two prostate cancer susceptibility loci were identified on chromosome 17q. The first locus, at 17q12, was distinguished by two intronic single-nucleotide polymorphisms (SNPs) in the TCF2 gene (rs4430796 and rs7501939). The second locus was in a gene-poor region of 17q24, where the strongest evidence of association was for SNP rs1859962. To determine if these loci were also associated with hereditary prostate cancer, we genotyped them in a family-based association sample of 403 non-Hispanic white families, including 1,015 men with and without prostate cancer. SNPs rs4430796 and rs7501939, which were in strong linkage disequilibrium (r(2) = 0.68), showed the strongest evidence of prostate cancer association. Using a family-based association test, the A allele of SNP rs4430796 was overtransmitted to affected men (P = 0.006), with an odds ratio of 1.40 (95% confidence interval, 1.09-1.81) under an additive genetic model. Notably, rs4430796 was significantly associated with prostate cancer among men diagnosed at an early (<50 years) but not later age (P = 0.006 versus P = 0.118). Our results confirm the prostate cancer association with SNPs on chromosome 17q12 initially reported by Gudmundsson and colleagues. In addition, our results suggest that the increased risk associated with these SNPs is approximately doubled in individuals predisposed to develop early-onset disease. Importantly, these SNPs do not account for a significant portion of our prior prostate cancer linkage evidence on chromosome 17. Thus, there likely exist one or more additional independent prostate cancer susceptibility loci in this region.
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