ArticleCancer research2008
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.Carcinogenesis · 2011Trial
- Harnessing the DNA Repair Pathway in Breast Cancer: Germline Mutations/Polymorphisms in Breast Radiation.Seminars in radiation oncology · 2022Review
- Review
- The Implications of Genetic Testing on Radiation Therapy Decisions: A Guide for Radiation Oncologists.International journal of radiation oncology, biology, physics · 2019Review
- ATM in breast and brain tumors: a comprehensive review.Cancer biology & medicine · 2018Article
- Contralateral prophylactic mastectomy rate and predictive factors among patients with breast cancer who underwent multigene panel testing for hereditary cancer.Cancer medicine · 2018Article
- Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- Ataxia-telangiectasia gene (Current oncology (Toronto, Ont.) · 2018Review
- Genetic determinants of sporadic breast cancer in Sri Lankan women.BMC cancer · 2018Article
- Men seeking counselling in a Breast Cancer Risk Evaluation Clinic.Ecancermedicalscience · 2018Article
- Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study.Journal of the National Cancer Institute · 2017Article
- ATM, radiation, and the risk of second primary breast cancer.International journal of radiation biology · 2017Review
- Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.Journal of experimental & clinical cancer research : CR · 2016Article
- Counselling framework for moderate-penetrance cancer-susceptibility mutations.Nature reviews. Clinical oncology · 2016Review
- Suppression of Akt-mTOR pathway-a novel component of oncogene induced DNA damage response barrier in breast tumorigenesis.PloS one · 2014Article
- Two-phase and family-based designs for next-generation sequencing studies.Frontiers in genetics · 2013Review
- Molecular defects in Moroccan patients with ataxia-telangiectasia.Neuromolecular medicine · 2013Article
- A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk.International journal of genomics · 2013Article
- Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study.Leukemia & lymphoma · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 11 institutions in 3 countries.
Funding
Abstract
Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In this study, 708 women with asynchronous CBC served as cases and 1,397 women with unilateral breast cancer served as controls. ATM, a serine-threonine kinase, controls the cellular response to DNA double-strand breaks, and has been implicated in breast cancer risk. Complete mutation screening of the ATM gene in all 2,105 study participants identified 240 distinct sequence variants; only 15 were observed in >1% of subjects. Among the rare variants, deleterious alleles resulting in loss of ATM function were associated with a nonsignificant increase in risk of CBC. In contrast, carriers of common variants had a statistically significant reduction in risk of CBC. Four of these 15 variants were individually associated with a significantly decreased risk of second primary breast cancer [c.1899-55T>G, rate ratio (RR), 0.5; 95% confidence interval (CI), 0.3-0.8; c.3161C>G, RR, 0.5; 95% CI, 0.3-0.9; c.5558A>T, RR, 0.2; 95% CI, 0.1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.