ArticleThe Journal of biological chemistry2008
Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- A single center phase II study of ixazomib in patients with relapsed or refractory cutaneous or peripheral T-cell lymphomas.American journal of hematology · 2017Trial
- Activin A Promotes Differentiation of a Pathogenic Multicytokine IL-9-secreting CD4+ T Cell Population.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation.The Journal of allergy and clinical immunology · 2024Article
- BRD4-PRC2 represses transcription of T-helper 2-specific negative regulators during T-cell differentiation.The EMBO journal · 2023Article
- MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
- Fibroblast growth factor 2 upregulates ecto-5'-nucleotidase and adenosine deaminase via MAPK pathways in cultured rat spinal cord astrocytes.Purinergic signalling · 2020Article
- Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation.Scientific reports · 2020Article
- Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells.Frontiers in immunology · 2018Review
- Knockdown of LSD1 ameliorates the severity of rheumatoid arthritis and decreases the function of CD4 T cells in mouse models.International journal of clinical and experimental pathology · 2018Article
- The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function.Frontiers in immunology · 2017Review
- Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.Nature communications · 2016Article
- Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells.Immunology · 2016Article
- The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells.PloS one · 2016Article
- Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.Advances in immunology · 2016Review
- Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.The Journal of biological chemistry · 2015Article
- Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation.Immunology and cell biology · 2015Review
- GATA-3 dose-dependent checkpoints in early T cell commitment.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells.Cytotechnology · 2014Article
- Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.Nature immunology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of naive CD4 T cells into Th2 cells requires the T cell receptor-mediated activation of the ERK MAPK cascade. Little is known, however, in regard to how the ERK MAPK cascade regulates Th2 cell differentiation. We herein identified Gfi1 (growth factor independent-1) as a downstream target of the ERK MAPK cascade for Th2 cell differentiation. In the absence of Gfi1, interleukin-5 production and the change of histone modification at the interleukin-5 gene locus were severely impaired. Furthermore, the interferon gamma gene showed a striking activation in the Gfi1(-/-) Th2 cells. An enhanced ubiquitin/proteasome-dependent degradation of GATA3 protein was observed in Gfi1(-/-) Th2 cells, and the overexpression of GATA3 eliminated the defect of Th2 cell function in Gfi1-deficient Th2 cells. These data suggest that the T cell receptor-mediated induction of Gfi1 controls Th2 cell differentiation through the regulation of GATA3 protein stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.