ArticleBiological psychiatry2008
Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands.
Article in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The event-related potential components across psychiatric disorders: a systematic review and network meta-analysis.Molecular psychiatry · 2025Pooled it
- A Meta-analytic Review of Auditory Event-Related Potential Components as Endophenotypes for Schizophrenia: Perspectives From First-Degree Relatives.Schizophrenia bulletin · 2016Pooled it
- Trial
- Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors.Neuroscience · 2013Trial
- Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients.Schizophrenia research · 2009Trial
- Schizophrenia disrupts normative covariation of neural activity across modalities of perception.Journal of psychopathology and clinical science · 2026Article
- Task-based default mode network connectivity predicts cognitive impairment and negative symptoms in first-episode schizophrenia.Psychophysiology · 2024Article
- Deep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes.BMC psychiatry · 2023Article
- A Narrative Review of Speech and EEG Features for Schizophrenia Detection: Progress and Challenges.Bioengineering (Basel, Switzerland) · 2023Review
- Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort.Schizophrenia research · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG).Journal of neurodevelopmental disorders · 2021Review
- Biomarker Profiles in Psychosis Risk Groups Within Unaffected Relatives Based on Familiality and Age.Schizophrenia bulletin · 2021Article
- Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia: An ERP Study.Frontiers in psychiatry · 2021Article
- Envelope Following Response to 440 Hz Carrier Chirp-Modulated Tones Show Clinically Relevant Changes in Schizophrenia.Brain sciences · 2020Article
- Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features.Biomarkers in neuropsychiatry · 2020Article
- Electroencephalography and Event-Related Potential Biomarkers in Individuals at Clinical High Risk for Psychosis.Biological psychiatry · 2020Review
- A modality-specific dysfunction of pain processing in schizophrenia.Human brain mapping · 2020Article
- Magnetoencephalography for Schizophrenia.Neuroimaging clinics of North America · 2020Review
- P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients.Frontiers in psychiatry · 2020Article
5 more citing papers are in PubMed but not listed here.
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23 authors.
Funding
Abstract
backgroundN100 evoked potential amplitude and gating abnormalities have been widely observed in schizophrenia patients. However, previous studies have been inconclusive as to whether similar deficits are present in unaffected family members. The Consortium on the Genetics of Schizophrenia (COGS) is a multisite National Institute of Mental Health (NIMH) initiative examining neurocognitive and neurophysiological measures as endophenotypes for genetic studies of schizophrenia. We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes.
methodsEvoked potential data were acquired from 142 schizophrenia probands, 373 unaffected first-degree relatives, and 221 community comparison subjects (CCS), using an auditory paired-click stimulation paradigm. Amplitude of the N100 response to each click and the click 2/click 1 ratio were dependent variables. Heritability was estimated based on kinships using Solar v.2.1.2. Group differences were examined after subjects were categorized as either "broad" or "narrow," based on the presence (broad) or absence (narrow) of nonpsychotic psychiatric comorbidity.
resultsHeritability estimates were .40 and .29 for click1 and click2 amplitudes and .22 for the ratio. Broad and narrow patients both had impaired click 1 amplitudes. Broad relatives, but not narrow relatives, exhibited similar impairments. There were no group differences for either click 2 amplitude or the gating ratio.
conclusionsN100 amplitude is a heritable measure that is abnormal in patients and a subset of relatives for whom psychiatric comorbidity may be a genetically associated phenotype. Auditory N100 gating, although heritable, is less viable as a schizophrenia endophenotype.
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