ArticleGenes, brain, and behavior2008
Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues.
Article in Genes, brain, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- PTH-induced behavioral and metabolic alterations in mouse models of hyperparathyroidism.iScience · 2026Article
- Review
- Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.Frontiers in endocrinology · 2025Review
- Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.Journal of personalized medicine · 2023Review
- Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.Scientific reports · 2023Article
- Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).Journal of neuroendocrinology · 2022Review
- Article
- Thalamic integration of social stimuli regulating parental behavior and the oxytocin system.Frontiers in neuroendocrinology · 2018Review
- Gestational Exposure to the Synthetic Cathinone Methylenedioxypyrovalerone Results in Reduced Maternal Care and Behavioral Alterations in Mouse Pups.Frontiers in neuroscience · 2018Article
- Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons.Journal of neurophysiology · 2013Article
- Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors.Psychopharmacology · 2012Article
- Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.Biology of mood & anxiety disorders · 2012Article
- The neuroendocrine functions of the parathyroid hormone 2 receptor.Frontiers in endocrinology · 2012Article
- Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats.The Malaysian journal of medical sciences : MJMS · 2011Article
- Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.Behavioural brain research · 2011Article
- TIP39 modulates effects of novelty-induced arousal on memory.Genes, brain, and behavior · 2011Article
- Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.The Journal of comparative neurology · 2010Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Tuberoinfundibular peptide of 39 residues (TIP39) is synthesized by two groups of neurons, one in the subparafascicular area at the caudal end of the thalamus and the other in the medial paralemniscal nucleus within the lateral brainstem. The subparafascicular TIP39 neurons project to a number of brain regions involved in emotional responses, and these regions contain a matching distribution of a receptor for TIP39, the parathyroid hormone 2 receptor (PTH2-R). We have now evaluated the involvement of TIP39 in anxiety-related behaviors using mice with targeted null mutation of the TIP39 gene (Tifp39). Tifp39(-/-) mice (TIP39-KO) did not significantly differ from wild-type (WT) littermates in the open field, light/dark exploration and elevated plus-maze assays under standard test conditions. However, the TIP39-KO engaged in more active defensive burying in the shock-probe test. In addition, when tested under high illumination or after restraint, TIP39-KO displayed significantly greater anxiety-like behavior in the elevated plus-maze than WT. In a Pavlovian fear-conditioning paradigm, TIP39-KO froze more than WT during training and during tone and context recall but showed normal fear extinction. Disruption of TIP39 projections to the medial prefrontal cortex, lateral septum, bed nucleus of the stria terminalis, hypothalamus and amygdala likely account for the fear- and anxiety-related phenotype of TIP39-KO. Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.