ArticlePLoS biology2008
Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
99 citing papers in PubMed, 243 citations in OpenAlex.
- From the MMC Specification to Endosperm Cellularization in Arabidopsis: A Developmental-Handover Framework for Seed Initiation.Plants (Basel, Switzerland) · 2026Review
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- Uncovering epigenetic and transcriptional regulation of growth in Douglas-fir: identification of differential methylation regions in mega-sized introns.Plant biotechnology journal · 2024Article
- Revisiting the female germline cell development.Frontiers in plant science · 2024Review
- Article
- Cloning and expression analysis of DnMSI1 gene in orchid speciesPlant signaling & behavior · 2022Article
- Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes.PLoS genetics · 2022Article
- The Importance of Networking: Plant Polycomb Repressive Complex 2 and Its Interactors.Epigenomes · 2022Review
- Progressive DNA demethylation in epigenetic hybrids between parental plants with and without methylation of the transgene promoter.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- MethylScore, a pipeline for accurate and context-aware identification of differentially methylated regions from population-scale plant whole-genome bisulfite sequencing data.Quantitative plant biology · 2022Article
- Genome-wide Identification, Expression, and Functional Analysis ofFrontiers in genetics · 2022Article
- Evolution of CG Methylation Maintenance Machinery in Plants.Epigenomes · 2021Review
- Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues.Plants (Basel, Switzerland) · 2021Review
- Digital paradigm for Polycomb epigenetic switching and memory.Current opinion in plant biology · 2021Review
- Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation inInternational journal of molecular sciences · 2021Article
- Dynamics of DNA Methylation and Its Functions in Plant Growth and Development.Frontiers in plant science · 2021Review
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- Conservation of centromeric histone 3 interaction partners in plants.Journal of experimental botany · 2020Article
- DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation.Nature plants · 2020Article
- Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.International journal of molecular sciences · 2020Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parental genomic imprinting causes preferential expression of one of the two parental alleles. In mammals, differential sex-dependent deposition of silencing DNA methylation marks during gametogenesis initiates a new cycle of imprinting. Parental genomic imprinting has been detected in plants and relies on DNA methylation by the methyltransferase MET1. However, in contrast to mammals, plant imprints are created by differential removal of silencing marks during gametogenesis. In Arabidopsis, DNA demethylation is mediated by the DNA glycosylase DEMETER (DME) causing activation of imprinted genes at the end of female gametogenesis. On the basis of genetic interactions, we show that in addition to DME, the plant homologs of the human Retinoblastoma (Rb) and its binding partner RbAp48 are required for the activation of the imprinted genes FIS2 and FWA. This Rb-dependent activation is mediated by direct transcriptional repression of MET1 during female gametogenesis. We have thus identified a new mechanism required for imprinting establishment, outlining a new role for the Retinoblastoma pathway, which may be conserved in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.