ArticlePLoS medicine2008
Children are not just small adults: the urgent need for high-quality trial evidence in children.
Article in PLoS medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- Drug interventions for acute treatment of pediatric migraine: a systematic review and network meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs.BMC medicine · 2023Pooled it
- Clinical care of children and adolescents with COVID-19: recommendations from the National COVID-19 Clinical Evidence Taskforce.The Medical journal of Australia · 2022Guideline
- Use of Facebook, Instagram, and Twitter for recruiting healthy participants in nutrition-, physical activity-, or obesity-related studies: a systematic review.The American journal of clinical nutrition · 2022Pooled it
- Facilitators and barriers of children's participation in nutrition, physical activity, and obesity interventions: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Randomized controlled trials in children's heart surgery in the 21st century: a systematic review.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2018Pooled it
- Pooled it
- Sample size calculations in pediatric clinical trials conducted in an ICU: a systematic review.Trials · 2014Pooled it
- Safety of medical interventions in children versus adults.Pediatrics · 2014Pooled it
- Quantifying bias in randomized controlled trials in child health: a meta-epidemiological study.PloS one · 2014Pooled it
- Pooled it
- A descriptive analysis of a representative sample of pediatric randomized controlled trials published in 2007.BMC pediatrics · 2010Pooled it
- Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children.The Cochrane database of systematic reviews · 2010Pooled it
- A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.BMC pediatrics · 2009Pooled it
- Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study.Advances in therapy · 2024Trial
- Trial
- Journal of child health care : for professionals working with children in the hospital and community · 2022Trial
- Using a Respectful Approach to Child-centred Healthcare (ReACH) in a paediatric clinical trial: A feasibility study.PloS one · 2020Trial
- Trial
- Randomized trial of adjunctive topiramate therapy in infants with refractory partial seizures.Neurology · 2010Trial
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Comment on
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.