Evidence map›Paper›PMID 1870029›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society1991

Mesenchymal stem cells.

A I Caplan

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1,486 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,486citing papers in PubMed, 2 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00550524 phase1unknown statusnot on this mapstarted 2007, after this paper: background citation

Phase 1 Study of Bone Marrow - Derived Stem Cell for the Treatment of Knee Osteoarthritis

TypeinterventionalSponsorTehran University of Medical SciencesRan2007 to 2010Enrolled5ConditionsKnee OsteoarthritisArmsAutologous Stem Cell Transplantation
NCT01687777 phase2unknown statusnot on this mapstarted 2010, after this paper: background citation

Treatment of Rotator Cuff Tears Using Autologous Bone Marrow Mensenchymal Stem Cell Transplantation.

TypeinterventionalSponsorHospital San Carlos, MadridRan2010 to 2013Enrolled10ConditionsChronic DiseaseArmsMesenchymal Stem Cells (MSCs), OrthADAPT
NCT07213726 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System

TypeinterventionalSponsorAndrews Research & Education FoundationRan2022 to 2026Enrolled15ConditionsBlood Flow Restriction (BFR) Training EffectsArmsDelfi Personalized Tourniquet System
3 · Its place in the literature

Who cites it

1,486 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6,475 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

1,426 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

A I CaplanDepartment of Biology, Case Western Reserve University, Cleveland, Ohio 44106.
Case Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end-stage cells involved with fabrication of a unique tissue type, e.g., cartilage or bone. Local cuing (extrinsic factors) and the genomic potential (intrinsic factors) interact at each lineage step to control the rate and characteristic phenotype of the cells in the emerging tissue. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self-cell repair. The isolation, mitotic expansion, and site-directed delivery of autologous stem cells can govern the rapid and specific repair of skeletal tissues.

Indexed as

Bone DevelopmentAnimalsCartilageChick EmbryoHumansMesodermMiceOsteoblastsStem Cells

Identifiers

PMID1870029
OpenAlexW2144268541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.