ArticleJournal of controlled release : official journal of the Controlled Release Society2008
A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 79 citations in OpenAlex.
- Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria.Vaccine · 2012Trial
- Transcutaneous Administration of Imiquimod Promotes T and B Cell Differentiation into Effector Cells or Plasma Cells.Pharmaceutics · 2022Article
- Article
- Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications.Pharmaceutics · 2021Review
- Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles andMaterials (Basel, Switzerland) · 2021Article
- Characteristic of K3 (CpG-ODN) as a Transcutaneous Vaccine Formulation Adjuvant.Pharmaceutics · 2020Article
- Immunogenicity of Milk Protein-Containing Hydrophilic Gel Patch for Epicutaneous Immunotherapy for Milk Allergy.Pharmaceutical research · 2020Article
- Toxoid Vaccination against Bacterial Infection Using Cell Membrane-Coated Nanoparticles.Bioconjugate chemistry · 2018Review
- A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8Frontiers in immunology · 2018Article
- Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant.Advanced functional materials · 2016Article
- Review
- Frontiers of transcutaneous vaccination systems: novel technologies and devices for vaccine delivery.Vaccine · 2013Review
- Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo.International journal of nanomedicine · 2011Article
- Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery.Biomaterials · 2010Article
- Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.PloS one · 2010Article
- Layer-by-layer-assembled multilayer films for transcutaneous drug and vaccine delivery.ACS nano · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most important anthropic missions is preventing the global spread of infectious diseases. Vaccination is the only available preventive treatment for infectious diseases, but the availability of vaccines in developing countries is not adequate. We report a simple, easy-to-use, noninvasive hydrogel patch transcutaneous vaccination system. Antigen (Ag)-specific IgG production was induced by applying an Ag-immersed patch to non-pretreated mouse auricle or hairless rat back skin. Immunofluorescence histochemical analysis revealed that Langerhans cells resident in the epidermal layer captured the antigenic proteins delivered by the hydrogel patch, which promoted the penetration of antigenic proteins through the stratum corneum, and that Ag-capturing Langerhans cells migrated into draining lymph nodes. Humoral immunity elicited by our transcutaneous vaccination system demonstrated neutralizing activity in both adenoviral infection and passive-challenge tetanus toxin experiments. The use of this hydrogel patch transcutaneous vaccination system will facilitate the global distribution of effective and convenient vaccines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.